About: A “Cute Desensitization of TRPV1

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Upon stimulation, the calcium influx via the vanilloid TRPV1 channels acutely desensitizes the channels themselves, which, from the cellular point of view, represents a feedback mechanism protecting the nociceptive neuron from toxic calcium overload. This review attempts to cover historical aspects of research into this process, tries to highlight some new challenging thoughts on the important phenomenon of TRPV1 desensitization and focuses on the putative molecular mechanisms that are thought to account for the acute phase of this process (acute desensitization’) Upon stimulation, the calcium influx via the vanilloid TRPV1 channels acutely desensitizes the channels themselves, which, from the cellular point of view, represents a feedback mechanism protecting the nociceptive neuron from toxic calcium overload. This review attempts to cover historical aspects of research into this process, tries to highlight some new challenging thoughts on the important phenomenon of TRPV1 desensitization and focuses on the putative molecular mechanisms that are thought to account for the acute phase of this process (acute desensitization’) (en)
Title	A “Cute Desensitization of TRPV1 A “Cute Desensitization of TRPV1 (en)
skos:prefLabel	A “Cute Desensitization of TRPV1 A “Cute Desensitization of TRPV1 (en)
skos:notation	RIV/67985823:_____/11:00358917!RIV12-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(GA305/09/0081), P(GAP301/10/1159), P(IAA600110701), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Maršáková, Lenka Touška, Filip Vlachová, Viktorie Teisinger, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	183752
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/11:00358917
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	capsaicin; analgesia; vanilloid receptor (en)
http://linked.open.../riv/klicoveSlovo	analgesia capsaicin vanilloid receptor
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[8BCE489F754F]
http://linked.open...i/riv/nazevZdroje	Current Pharmaceutical Biotechnology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Structural and functional determinants on TRPV channels Structural and functional determinants on TRPM5 and TRPM8 channels Neuroscience Centre Activation and regulation mechanisms of nociceptor-specific transient receptor potential channels: physiological role in acute and chronic pain
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Maršáková, Lenka Teisinger, Jan Touška, Filip Vlachová, Viktorie
http://linked.open...ain/vavai/riv/wos	000286589900014
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1389-2010
number of pages	8 (xsd:int)

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