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rdf:type
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Description
| - Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF73)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein–Barr virus induced gene 2 (Ebi2), which lies at this locus and controls B lymphocyte migration is expressed in macrophages and regulates the IDIN. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D). These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D
- Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF73)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein–Barr virus induced gene 2 (Ebi2), which lies at this locus and controls B lymphocyte migration is expressed in macrophages and regulates the IDIN. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D). These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D (en)
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Title
| - A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
- A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk (en)
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skos:prefLabel
| - A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
- A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk (en)
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skos:notation
| - RIV/67985823:_____/10:00348257!RIV11-GA0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0520), P(GAP301/10/0290), Z(AV0Z50110509)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/10:00348257
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - IRF7 driven inflammatory network; Ebi2; type 1 diabetes (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bauerfeind, A.
- Pravenec, Michal
- Wallace, C.
- Ziegler, A.
- Cooper, J.
- Bottolo, L.
- Buchan, R.
- Cook, S. A.
- Hubner, N.
- Lu, H.
- Petretto, E.
- Aitman, T. J.
- Heinig, M.
- Vingron, M.
- Zeller, T.
- Blankenberg, S.
- Li, Y.
- Samani, N. J.
- Cambien, F.
- Clayton, D.
- Cyster, J. G.
- Erdmann, J.
- Goodall, A. H.
- Gray, C. C.
- Hengstenberg, C.
- Hummel, O.
- Langley, S. R.
- Lee, Y. A.
- Maouche, S.
- Münzel, T.
- Ouwehand, W. H.
- Paskas, S.
- Rice, C. M.
- Rintisch, C.
- Roider, H. G.
- Rotival, M.
- Saar, K.
- Sarwar, R.
- Schulz, H.
- Schunkert, H.
- Smyth, D. J.
- Szymczak, S.
- Tiret, L.
- Todd, J. A.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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