About: Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits

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About: Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Our data support the view that the mechanism of the long-term adaptation to high doses of morphine is primarily based on desensitization of opioid receptors-response preferentially oriented to micro- and delta-opioid receptors. Prolonged exposure of rats to high doses of morphine results in decrease of the over-all output of opioid receptors-stimulated G-protein activity in the forebrain cortex but does not decrease the amount of these regulatory proteins Our data support the view that the mechanism of the long-term adaptation to high doses of morphine is primarily based on desensitization of opioid receptors-response preferentially oriented to micro- and delta-opioid receptors. Prolonged exposure of rats to high doses of morphine results in decrease of the over-all output of opioid receptors-stimulated G-protein activity in the forebrain cortex but does not decrease the amount of these regulatory proteins (en)
Title	Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits (en)
skos:prefLabel	Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits (en)
skos:notation	RIV/67985823:_____/10:00348192!RIV11-MSM-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500110606), P(LC554), Z(AV0Z50110509), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Svoboda, Petr Vošahlíková, Miroslava Roubalová, Lenka Dlouhá, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	268884
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/10:00348192
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	morphine; G-protein; opioid receptors (en)
http://linked.open.../riv/klicoveSlovo	opioid receptors G-protein morphine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[82A588708D80]
http://linked.open...i/riv/nazevZdroje	Medical Science Monitor
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuroscience Centre Delta-opioid receptor targeting to membrane domains: the role of palmitoylation
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Novotný, J. Svoboda, Petr Dlouhá, Kateřina Vošahlíková, Miroslava Bouřová, Lenka Kagan, D.
http://linked.open...ain/vavai/riv/wos	280762400008
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Signaling and cellular response mechanisms
issn	1234-1010
number of pages	11 (xsd:int)

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