About: The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801     Goto   Sponge   NotDistinct   Permalink

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  • The manipulation of glutamate neurotransmission could represent a potential strategy for the pharmacotherapy of schizophrenic symptoms. In our study we evaluated the effect of agonists and allosteric modulators of mGluR2/3 and mGluR5 on performance in a cognitive task in animal model of schizophrenia like behavior. The results show that application of the mGlu2/3 receptor agonist had no effect on cognitive impairment. However, the mGlu5 receptor agonists ameliorated cognitive impairment without affecting locomotion
  • The manipulation of glutamate neurotransmission could represent a potential strategy for the pharmacotherapy of schizophrenic symptoms. In our study we evaluated the effect of agonists and allosteric modulators of mGluR2/3 and mGluR5 on performance in a cognitive task in animal model of schizophrenia like behavior. The results show that application of the mGlu2/3 receptor agonist had no effect on cognitive impairment. However, the mGlu5 receptor agonists ameliorated cognitive impairment without affecting locomotion (en)
Title
  • The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801
  • The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801 (en)
skos:prefLabel
  • The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801
  • The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801 (en)
skos:notation
  • RIV/67985823:_____/10:00344048!RIV11-AV0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR9178), V, Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 1-3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 254344
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  • RIV/67985823:_____/10:00344048
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  • animal model of schizophrenia; metabotropic glutamate receptor; cognition (en)
http://linked.open.../riv/klicoveSlovo
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  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [93BF0215D116]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Pharmacology
http://linked.open...in/vavai/riv/obor
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  • 639
http://linked.open...iv/tvurceVysledku
  • Bubeníková-Valešová, V.
  • Stuchlík, Aleš
  • Svoboda, Jan
  • Valeš, Karel
  • Benkovičová, Kristína
http://linked.open...ain/vavai/riv/wos
  • 279066800011
http://linked.open...n/vavai/riv/zamer
issn
  • 0014-2999
number of pages
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