About: Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

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About: Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The article focuses on the problematic of temperature dependence of deactivation of native N-Methyl-D-Aspartate (NMDA) receptors in neuronal cultures and the temperature dependence of excitatory postsynaptic currents mediated by synaptic NMDA receptors in rat cortical slices. Our electrophysiology experiments found that both native as well as synaptic receptors exhibit significantly weaker temperature dependence compared to recombinant GluN1/GluN2B NMDA receptors. Synaptic NMDA receptors have characteristics of receptors with low desensitization (20%). Double exponential time course of NMDA receptor deactivation originates mainly from dissociation of agonist and desensitization The article focuses on the problematic of temperature dependence of deactivation of native N-Methyl-D-Aspartate (NMDA) receptors in neuronal cultures and the temperature dependence of excitatory postsynaptic currents mediated by synaptic NMDA receptors in rat cortical slices. Our electrophysiology experiments found that both native as well as synaptic receptors exhibit significantly weaker temperature dependence compared to recombinant GluN1/GluN2B NMDA receptors. Synaptic NMDA receptors have characteristics of receptors with low desensitization (20%). Double exponential time course of NMDA receptor deactivation originates mainly from dissociation of agonist and desensitization (en)
Title	Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents (en)
skos:prefLabel	Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents (en)
skos:notation	RIV/67985823:_____/10:00342116!RIV11-GA0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(GA309/07/0271), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Dittert, Ivan Sedláček, Miloslav Vyklický ml., Ladislav Kořínek, Miloslav Cais, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	292188
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/10:00342116
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hypothermia; patch-clamp recording (en)
http://linked.open.../riv/klicoveSlovo	patch-clamp recording hypothermia
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[50074168B17E]
http://linked.open...i/riv/nazevZdroje	Neuroscience
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of the effects of neurosteroids and temperature on NMDA receptors Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Neuroscience Centre
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	165
http://linked.open...iv/tvurceVysledku	Vyklický ml., Ladislav Cais, Ondřej Kořínek, Miroslav Dittert, Ivan Sedláček, Miloslav
http://linked.open...ain/vavai/riv/wos	274002600011
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0306-4522
number of pages	13 (xsd:int)

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