About: Peroxidative damage of mitochondrial respiration is substrate-dependent

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The concentration-dependence of tert-butyl hydroperoxide (BHP) inhibitory effect on oxygen consumption in isolated rat liver mitochondria was measured in the presence of various respiratory substrates. Strong inhibitory effect at low concentrations of BHP (15-30 µM) was found for oxoglutarate and palmitoyl carnitine oxidation. Our data indicate that beside peroxidative damage of complex I also various mitochondrial NADH-dependent dehydrogenases are inhibited but to a different extent and with different kinetics. Our data also show that succinate could be an important nutritional substrate protecting hepatocytes during peroxidative damage The concentration-dependence of tert-butyl hydroperoxide (BHP) inhibitory effect on oxygen consumption in isolated rat liver mitochondria was measured in the presence of various respiratory substrates. Strong inhibitory effect at low concentrations of BHP (15-30 µM) was found for oxoglutarate and palmitoyl carnitine oxidation. Our data indicate that beside peroxidative damage of complex I also various mitochondrial NADH-dependent dehydrogenases are inhibited but to a different extent and with different kinetics. Our data also show that succinate could be an important nutritional substrate protecting hepatocytes during peroxidative damage (en)
Title	Peroxidative damage of mitochondrial respiration is substrate-dependent Peroxidative damage of mitochondrial respiration is substrate-dependent (en)
skos:prefLabel	Peroxidative damage of mitochondrial respiration is substrate-dependent Peroxidative damage of mitochondrial respiration is substrate-dependent (en)
skos:notation	RIV/67985823:_____/09:00338968!RIV10-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/06/1261), Z(AV0Z50110509), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Nůsková, Hana Drahota, Zdeněk Rauchová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	333120
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/09:00338968
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mitochondrial enzymes; peroxidative damage; tert-butyl hydroperoxide (en)
http://linked.open.../riv/klicoveSlovo	peroxidative damage tert-butyl hydroperoxide mitochondrial enzymes
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B38951D8C97E]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Pathophysiological function of mitochondrial glycerophopsphate dehydrogenase - production of reactive oxygen species
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Drahota, Zdeněk Nůsková, Hana Rauchová, Hana Endlicher, R. Červinková, Z. Křiváková, P.
http://linked.open...ain/vavai/riv/wos	272080200009
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0862-8408
number of pages	8 (xsd:int)

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