About: Impaired control of L-type voltage-dependent calcium channels in experimental hypertension

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About: Impaired control of L-type voltage-dependent calcium channels in experimental hypertension Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Most of the forms of experimental hypertension are associated with sympathetic hyperactivity and endothelial dysfunction. It is evident that nitric oxide and norepinephrine are antagonists in the control of calcium influx through L-type voltage-dependent calcium channels (L-VDCC). Their effects on L-VDCC are mediated by cGMP and cAMP, respectively. Rats with genetic or salt hypertension are characterized by a relative (but not absolute) NO deficiency compared to the absolute enhancement of sympathetic vasoconstriction. This dysbalance of vasoconstrictor and vasodilator systems in hypertensive animals is reflected by greater calcium influx through L-VDCC susceptible to the inhibition by nifedipine Most of the forms of experimental hypertension are associated with sympathetic hyperactivity and endothelial dysfunction. It is evident that nitric oxide and norepinephrine are antagonists in the control of calcium influx through L-type voltage-dependent calcium channels (L-VDCC). Their effects on L-VDCC are mediated by cGMP and cAMP, respectively. Rats with genetic or salt hypertension are characterized by a relative (but not absolute) NO deficiency compared to the absolute enhancement of sympathetic vasoconstriction. This dysbalance of vasoconstrictor and vasodilator systems in hypertensive animals is reflected by greater calcium influx through L-VDCC susceptible to the inhibition by nifedipine (en)
Title	Impaired control of L-type voltage-dependent calcium channels in experimental hypertension Impaired control of L-type voltage-dependent calcium channels in experimental hypertension (en)
skos:prefLabel	Impaired control of L-type voltage-dependent calcium channels in experimental hypertension Impaired control of L-type voltage-dependent calcium channels in experimental hypertension (en)
skos:notation	RIV/67985823:_____/09:00338019!RIV10-MSM-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(GA305/08/0139), P(GA305/09/0336), P(IAA500110902), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	Suppl.2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Líšková, Silvia Zicha, Josef Pintérová, Mária Kuneš, Jaroslav Dobešová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	318661
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/09:00338019
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	calcium-activated K+ and Cl- channels; vasoactive systems; EDCF (en)
http://linked.open.../riv/klicoveSlovo	vasoactive systems EDCF calcium-activated K+ and Cl- channels
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[A232D19BC8A0]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Altered regulation of vasoactive system balance in experimental hypertension Centre for cardiovascular research Mechanisms of antihypertensive action of high potassium intake in salt hypertension Neurohumoral control of calcium influx: nifedipine-sensitive component of blood pressure in experimental hypertension
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Kuneš, Jaroslav Pintérová, Mária Zicha, Josef Líšková, Silvia Dobešová, Zdenka Behuliak, M.
http://linked.open...ain/vavai/riv/wos	273537200005
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	12 (xsd:int)

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