About: Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats

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About: Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Melatonin reduces blood pressure, enhances nitric oxide availability and scavenges free radicals, but there are few data about the effect of melatonin treatment on left ventricular remodeling associated with hemodynamic overload. Chronic melatonin treatment prevented the development of left ventricular fibrosis and the increase in oxidative load in rats with L-NAME-induced hypertension. The antifibrotic effect of melatonin is independent of its effects on NO synthase activity and might be linked to its antioxidant properties Melatonin reduces blood pressure, enhances nitric oxide availability and scavenges free radicals, but there are few data about the effect of melatonin treatment on left ventricular remodeling associated with hemodynamic overload. Chronic melatonin treatment prevented the development of left ventricular fibrosis and the increase in oxidative load in rats with L-NAME-induced hypertension. The antifibrotic effect of melatonin is independent of its effects on NO synthase activity and might be linked to its antioxidant properties (en)
Title	Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats (en)
skos:prefLabel	Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats (en)
skos:notation	RIV/67985823:_____/09:00330732!RIV10-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/08/0139), Z(AV0Z50110509), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	Suppl.6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pecháňová, Olga Zicha, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	325291
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/09:00330732
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hypertension; cardiac hypertrophy; collagen (en)
http://linked.open.../riv/klicoveSlovo	cardiac hypertrophy collagen hypertension - ischaemic heart disease - cardiac failure - vitamin D
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F0741764D4D5]
http://linked.open...i/riv/nazevZdroje	Journal of Hypertension
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Altered regulation of vasoactive system balance in experimental hypertension
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Zicha, Josef Pecháňová, Olga Paulis, L. Adamcová, M. Barta, A. Šimko, F. Krajčírovičová, K. Pelouch, V.
http://linked.open...ain/vavai/riv/wos	269549400003
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0263-6352
number of pages	6 (xsd:int)

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