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rdf:type
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Description
| - Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. We investigate the systemic effect of a D1R agonist (A77636) and antagonist (SCH 23390) on hyperlocomotor activity and cognitive deficit induced by an NMDA receptor antagonist (MK-801). Administration of the D1R antagonist had no effect on cognitive function, but decreased hyperlocomotion induced by MK-801. Thus, based on our results, over-activation of D1Rs may exacerbate psychotic symptoms in patients with schizophrenia
- Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. We investigate the systemic effect of a D1R agonist (A77636) and antagonist (SCH 23390) on hyperlocomotor activity and cognitive deficit induced by an NMDA receptor antagonist (MK-801). Administration of the D1R antagonist had no effect on cognitive function, but decreased hyperlocomotion induced by MK-801. Thus, based on our results, over-activation of D1Rs may exacerbate psychotic symptoms in patients with schizophrenia (en)
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Title
| - The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats
- The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats (en)
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skos:prefLabel
| - The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats
- The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats (en)
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skos:notation
| - RIV/67985823:_____/09:00328539!RIV10-MSM-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0517), P(GA309/07/0341), P(NR9178), Z(AV0Z50110509), Z(MZ0PCP2005)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/09:00328539
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - animal model; cognitive function; D1 receptor (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - International Journal of Neuropsychopharmacology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bubeníková-Valešová, V.
- Horáček, J.
- Svoboda, Jan
- Valeš, Karel
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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