About: Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions

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About: Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The T4 treatment resulted in an increased susceptibility of young, but not adult rat hearts to a hypokalemia-induced VF and facilitated a spontaneous sinus rhythm (SSR) restoration in the latter group. The acute T3 administration of in the range of 10-9-10-7 mol/l significantly decreased the susceptibility of an isolated heart to an electrically induced VF and also facilitated the sinus rhythm restoration. The SSR restoration was, however, not affected by 10-6 mol/l concentration of T3, which in addition, led to an increased VF susceptibility. Results indicate that TH can affect the susceptibility of the heart to VF and its ability to restore the sinus rhythm via fast acute (non-genomic) and long lasting chronic (genomic) actions. Furthermore, an anti- and pro-arrhythmic potential of TH appears to be age- and dose-dependent The T4 treatment resulted in an increased susceptibility of young, but not adult rat hearts to a hypokalemia-induced VF and facilitated a spontaneous sinus rhythm (SSR) restoration in the latter group. The acute T3 administration of in the range of 10-9-10-7 mol/l significantly decreased the susceptibility of an isolated heart to an electrically induced VF and also facilitated the sinus rhythm restoration. The SSR restoration was, however, not affected by 10-6 mol/l concentration of T3, which in addition, led to an increased VF susceptibility. Results indicate that TH can affect the susceptibility of the heart to VF and its ability to restore the sinus rhythm via fast acute (non-genomic) and long lasting chronic (genomic) actions. Furthermore, an anti- and pro-arrhythmic potential of TH appears to be age- and dose-dependent (en)
Title	Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions (en)
skos:prefLabel	Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions Thyroid hormones modulate occurrence and termination of ventricular fibrillation by both long-term and acute actions (en)
skos:notation	RIV/67985823:_____/08:00338076!RIV10-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/05/0327), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	Suppl.2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Soukup, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	400021
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/08:00338076
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ventricular fibrillation; sinus rhythm restoration; thyroid hormone (en)
http://linked.open.../riv/klicoveSlovo	ventricular fibrillation thyroid hormone sinus rhythm restoration
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[39A25CF54494]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Influence of thyroid hormones on expression of myofibrillar and Ca2+ transporting proteins
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Soukup, Tomáš Tribulová, N. Knezl, V. Slezák, J. Okruhlicová, L.
http://linked.open...ain/vavai/riv/wos	258078700012
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	6 (xsd:int)

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