About: Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin

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About: Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Naše zjištění vneslo pochybnosti o dosavadních představách založených na posttranslační modifikaci TRPV1 proteinu a závislosti na procesu fosforylace/defosforylace. Autoři dochází k závěru, že problém není dosud dořešen a je součástí komplexu otázek, na něž je nutné odpovědět, abychom porozuměli mechanizmům, které se uplatňují v analgetických účincích kapsaicinu (cs) This review summarizes the current state of knowledge concerning the mechanisms that underlie the acute capsaicin-induced calcium-dependent desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia. In view of the polymodal nature of TRPV1, we illustrate how the channels behave in their desensitized state when activated by noxious heat or depolarizing voltages. We provide a possible explanation for a high incidence of adverse effects of topical capsaicin and point to a need for more accurate clinical criteria for employing it as a reliable remedy This review summarizes the current state of knowledge concerning the mechanisms that underlie the acute capsaicin-induced calcium-dependent desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia. In view of the polymodal nature of TRPV1, we illustrate how the channels behave in their desensitized state when activated by noxious heat or depolarizing voltages. We provide a possible explanation for a high incidence of adverse effects of topical capsaicin and point to a need for more accurate clinical criteria for employing it as a reliable remedy (en)
Title	Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin (en) Desenzitizace vaniloidního receptoru TRPV1 závislá na vápníku: Možný mechanizmus analgetického účinku lokálně aplikovaného kapsaicinu (cs)
skos:prefLabel	Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin (en) Desenzitizace vaniloidního receptoru TRPV1 závislá na vápníku: Možný mechanizmus analgetického účinku lokálně aplikovaného kapsaicinu (cs)
skos:notation	RIV/67985823:_____/08:00320367!RIV09-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(GA305/06/0319), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	Suppl.3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Touška, Filip Vlachová, Viktorie Nováková-Toušová, Karolina Benedikt, Jan Vyklický, Ladislav Samad, Abdul
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	358723
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/08:00320367
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TRPV1 receptors; capsaicin; analgesia (en)
http://linked.open.../riv/klicoveSlovo	analgesia capsaicin TRPV1 receptors
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D641C2DA32EC]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Molecular and Functional Characterization of Nociceptor-specific TRP Channels: A Physiological Role in Acute and Chronic Pain Neuroscience Centre
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Benedikt, Jan Samad, Abdul Touška, Filip Vlachová, Viktorie Vyklický st., Ladislav Nováková-Toušová, Karolina
http://linked.open...ain/vavai/riv/wos	262473500007
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	10 (xsd:int)

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