About: Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake

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About: Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pomalu metabolizující proteiny, např. kolagen a elastin akumulují reaktivní metabolity, vznikající ne-enzymatickými reakcemi např. glykací. Typickým příkladem těchto neenzymatických změn je tvorba pokročilých glykačních produktů (AGEs), vznikajících reakcí cukrů s volnou amino skupinou proteinů. Chronická hyperglykémie zapříčinila výrazné zvýšení koncentrace pentosidinu zejména v aortě a kůži tří kmenů potkanů (cs) The slowly metabolized proteins of the extracellular matrix, typically collagen and elastin, accumulate reactive metabolites through uncontrolled non-enzymatic reactions such as glycation or the products arising from the reaction of unsaturated long chain fatty acid metabolites (possessing aldehydic groups). A typical example of these non-enzymatic changes is the formation of advanced glycation end-products (AGEs), resulting from the reaction of carbohydrates with the free amino group of proteins. Chronic (three-week) hyperglycemia (resulting from fructose loading) caused a significant increase in pentosidine concentration mainly in the aorta and skin of the three rat strains The slowly metabolized proteins of the extracellular matrix, typically collagen and elastin, accumulate reactive metabolites through uncontrolled non-enzymatic reactions such as glycation or the products arising from the reaction of unsaturated long chain fatty acid metabolites (possessing aldehydic groups). A typical example of these non-enzymatic changes is the formation of advanced glycation end-products (AGEs), resulting from the reaction of carbohydrates with the free amino group of proteins. Chronic (three-week) hyperglycemia (resulting from fructose loading) caused a significant increase in pentosidine concentration mainly in the aorta and skin of the three rat strains (en)
Title	Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake (en) Pentosidin, produkt pokročilé glykace, hromadící se v různých tkáních potkanů s vysokou hladinou fruktózy (cs)
skos:prefLabel	Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake (en) Pentosidin, produkt pokročilé glykace, hromadící se v různých tkáních potkanů s vysokou hladinou fruktózy (cs)
skos:notation	RIV/67985823:_____/08:00306963!RIV08-AV0-67985823
http://linked.open.../vavai/riv/strany	89;94
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(GA203/05/2539), P(GA305/08/0108), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Zicha, Josef Kuneš, Jaroslav Mikšík, Ivan Eckhardt, Adam Lacinová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	354985
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/08:00306963
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	collagen; pentosidine; ages (en)
http://linked.open.../riv/klicoveSlovo	ages collagen pentosidine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[209E3FFFBF63]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Recovery from chonic lung hypoxia and effects of hypoxia in placenta. Pathophysiological basis for therapy. Centre for cardiovascular research Multidimensional separation and detection of biomolecules by high-performance capillary electromigration methods
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Kuneš, Jaroslav Zicha, Josef Mikšík, Ivan Eckhardt, Adam Mikulíková, Kateřina
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	6 (xsd:int)

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