About: The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension

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About: The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Attenuated NO formation and increased ROS formation are often found in human and experimental hypertension. Two antioxidants (NAC and melatonin) were chronically administered to SHR with established hypertension. Both treatments improved NO/ROS balance, but only melatonin lowered blood pressure. This indicates that antihypertensive effects of melatonin are independent of NO pathways Attenuated NO formation and increased ROS formation are often found in human and experimental hypertension. Two antioxidants (NAC and melatonin) were chronically administered to SHR with established hypertension. Both treatments improved NO/ROS balance, but only melatonin lowered blood pressure. This indicates that antihypertensive effects of melatonin are independent of NO pathways (en) Snížena tvorba NO a zvýšená produkce kyslíkových radikálů jsou často pozorovány u lidské i experimentální hypertenze. Spontánně hypertenzní potkani s rozvinutou hypertenzí dostávali chronicky dvě různá antioxidancia – NAC a melatonin. Obě látky zlepšovaly rovnováhu NO a kyslíkových radikálů, ale krevní tlak byl snižován pouze melatoninem. To naznačuje, že antihypertenzní účinky melatoninu jsou nezávislé na změnách tvorby NO (cs)
Title	The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension Účinek N-acetylcysteinu a melatoninu i dospělých spontánně hypertenzních potkanů s rozvinutou hypertenzí (cs) The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension (en)
skos:prefLabel	The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension Účinek N-acetylcysteinu a melatoninu i dospělých spontánně hypertenzních potkanů s rozvinutou hypertenzí (cs) The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension (en)
skos:notation	RIV/67985823:_____/07:00080986!RIV07-MZ0-67985823
http://linked.open.../vavai/riv/strany	129;136
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/03/0769), P(NR7786), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Pecháňová, Olga Zicha, Josef Kuneš, Jaroslav Dobešová, Zdeňka Paulis, Ľudovít
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	419017
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/07:00080986
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NO synthase; oxidative load; genetic hypertension (en)
http://linked.open.../riv/klicoveSlovo	oxidative load genetic hypertension NO synthase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[683B887E4886]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmacology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction of oxygen free radicals with nitric oxide in the development of endothelial dysfunction in hypertension The search for quantitative trait loci and candidate genes responsible for the pathogenesis of hypertension and metabolic syndrome
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	561
http://linked.open...iv/tvurceVysledku	Kuneš, Jaroslav Zicha, Josef Dobešová, Zdenka Pecháňová, Olga Paulis, Ľudovít Šimko, F. Sládková, M. Kojšová, S. Jendeková, L. Dovinová, I. Zenebe, W.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0014-2999
number of pages	8 (xsd:int)

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