About: beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits     Goto   Sponge   NotDistinct   Permalink

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Description
  • Zhoršení schopnosti se učit se po infůzi beta-amyloidu do mozku hlodavce se projeví až v delším odstupu a je znatelné jen u zvířat starých. Zhoršení koreluje s poklesem některých metabolitův v mozkomíšním moku, nekoreluje však s výskytem amyloidovými plaky. K poškození kognitivních schopností u hlodavců tudíž vede i malé zvýšení koncentrace beta-amyloidu v mozku aniž vznikne zánět nebo vzniknou amyloidová depozita (cs)
  • Learning deficit after the infusion of beta-amyloid into the rat brain is delayed and age dependent. The impairment corerelates with the decrease of some cerebrospinal fluid metabolites, but does not correlate with the appearing of amyloid plaques. Therefore even a subtle increase in brain beta-amyloid concentration may disrupt cognitive abilities in rats independent of inflammation or amyoid plaques load
  • Learning deficit after the infusion of beta-amyloid into the rat brain is delayed and age dependent. The impairment corerelates with the decrease of some cerebrospinal fluid metabolites, but does not correlate with the appearing of amyloid plaques. Therefore even a subtle increase in brain beta-amyloid concentration may disrupt cognitive abilities in rats independent of inflammation or amyoid plaques load (en)
Title
  • beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
  • Infúzní podání beta-Amyloidu vede k pozdnímu a věkově závislému poškození schopnosti se učit, a to i bez vlivu zánětu anebo beta-amyloidových depozit (cs)
  • beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits (en)
skos:prefLabel
  • beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits
  • Infúzní podání beta-Amyloidu vede k pozdnímu a věkově závislému poškození schopnosti se učit, a to i bez vlivu zánětu anebo beta-amyloidových depozit (cs)
  • beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits (en)
skos:notation
  • RIV/67985823:_____/06:00054429!RIV07-AV0-67985823
http://linked.open.../vavai/riv/strany
  • 8852;8857
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0517), P(GA309/06/1231), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 23
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 466760
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/06:00054429
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cerebrospinal fluid; learning; Alzheimer´s disease (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [E42EBD47FC6D]
http://linked.open...i/riv/nazevZdroje
  • Proceedings of the National Academy of Sciences of the United States of America
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 103
http://linked.open...iv/tvurceVysledku
  • Bureš, Jan
  • Ort, Michael
  • Koistinaho, J.
  • Koistinaho, M.
  • Goldsteins, G.
  • Laatikainen, R.
  • Ahtoniemi, T.
  • Frautschy, S. A.
  • Harris-White, M. E.
  • Jukarainen, N.
  • Kanninen, K.
  • Leskinen, S.
  • Malm, T.
  • Miettinen, T. K.
  • Nurmi, A.
  • Puoliväli, J.
  • Pussinen, R.
  • Tähtivaara, L.
  • Vartiainen, N.
  • Yrjänheikki, J.
http://linked.open...n/vavai/riv/zamer
issn
  • 0027-8424
number of pages
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