About: Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia

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About: Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim was to determine if the L-carnitine-dependent decrease of plasma lactate could be due to a modification of lactate dehydrogenase (LDH) activity. We found an increased of brain LDH activity with the age. However, we did not observe any significant differences in LDH activity after exposure to hypobaric hypoxia or L-carnitine pretreatment. In contrast to brain, serum LDH activity did not show any age-dependence. The hypoxia exposure increased LDH activity of 21-day-old rats only. Pretreatment of rats with L-carnitine decreased serum LDH activity of 21- and 90-day-old rats. In conclusion, acute hypobaric hypoxia and/or L-carnitine pretreatment modified serum but not brain LDH activity The aim was to determine if the L-carnitine-dependent decrease of plasma lactate could be due to a modification of lactate dehydrogenase (LDH) activity. We found an increased of brain LDH activity with the age. However, we did not observe any significant differences in LDH activity after exposure to hypobaric hypoxia or L-carnitine pretreatment. In contrast to brain, serum LDH activity did not show any age-dependence. The hypoxia exposure increased LDH activity of 21-day-old rats only. Pretreatment of rats with L-carnitine decreased serum LDH activity of 21- and 90-day-old rats. In conclusion, acute hypobaric hypoxia and/or L-carnitine pretreatment modified serum but not brain LDH activity (en) Cílem práce bylo určit, zda snížení laktátu v plazmě vyvolané podáním L-karnitinu bylo způsobeno modifikací laktátdehydrogenázy (LDH). LDH v mozku se zvyšovala s věkem, avšak nebyla ovlivněna hypobarickou hypoxií ani podáním L-karnitinu. Naproti tomu, sérová LDH nevykázala věkovou závislost. Vystavení akutní hypobarické hypoxii zvýšilo sérovou LDH u 21-denních potkanů. Podání L-karnitinu potkanům vystaveným hypobarické hypoxii snížilo sérovou LDH u 21- a 90-denních zvířat. Lze uzavřít, že akutní hypobarická hypoxie a/nebo L-karnitinové podání modifikovaly sérovou, ale ne mozkovou LDH (cs)
Title	Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia (en) Aktivita laktátdehydrogenázy v séru a mozkové kůře nezralých a zralých krys po hypobarické hypoxii (cs)
skos:prefLabel	Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia (en) Aktivita laktátdehydrogenázy v séru a mozkové kůře nezralých a zralých krys po hypobarické hypoxii (cs)
skos:notation	RIV/67985823:_____/06:00049130!RIV07-AV0-67985823
http://linked.open.../vavai/riv/strany	915;919
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(GA305/04/0500), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Vokurková, Martina Rauchová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	464090
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/06:00049130
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	brain; lactate dehydrogenase; hypoxia (en)
http://linked.open.../riv/klicoveSlovo	hypoxia lactate dehydrogenase brain
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C2CF2A9647C6]
http://linked.open...i/riv/nazevZdroje	Neurochemical Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Oxidative stress induced by acute and chonic hypoxia: metabolic changes and membrane alterations Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Rauchová, Hana Vokurková, Martina Koudelová, J.
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0364-3190
number of pages	5 (xsd:int)

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