About: Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application     Goto   Sponge   NotDistinct   Permalink

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Description
  • Účelem této studie bylo zhodnotit úlohu TRPV1-exprimujících nociceptorů v rozvoji pooperační allodynie a hyperalgesie jejich funkční inaktivací pomocí intradermální injekce capsaicinu ve vysoké koncentraci na krysím modelu plantární incise. Byly testovány reflexní odpovědi na mechanické a tepelné podněty aplikované na kůži planty pedis zvířat ovlivněných buď capsaicinem nebo jen rozpouštědlem. Naše výsledky prokázaly významnou úlohu TRPV1-exprimujících nociceptorů v rozvoji pooperační hypersensitivity a poukazují na možnost využití lokálně aplikovaného capsaicinu ve vysoké koncentraci k jejímu ovlivnění (cs)
  • The aim of this study was to evaluate the role of TRPV1 receptor-containing nociceptors in the development of post-operative allodynia and hyperalgesia by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model. Paw withdrawal responses to mechanical and thermal stimuli applied on plantar skin were tested in animals treated with capsaicin or the vehicle. Our results show an important role of TRPV1-containing nociceptors in the development of post-surgical hypersensitivity and suggest that local, high-concentration capsaicin treatment could be used to reduce it
  • The aim of this study was to evaluate the role of TRPV1 receptor-containing nociceptors in the development of post-operative allodynia and hyperalgesia by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model. Paw withdrawal responses to mechanical and thermal stimuli applied on plantar skin were tested in animals treated with capsaicin or the vehicle. Our results show an important role of TRPV1-containing nociceptors in the development of post-surgical hypersensitivity and suggest that local, high-concentration capsaicin treatment could be used to reduce it (en)
Title
  • Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application
  • Pooperační bolest je snížena po jednorázové aplikaci capsaicinu o vysoké koncentraci u krys (cs)
  • Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application (en)
skos:prefLabel
  • Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application
  • Pooperační bolest je snížena po jednorázové aplikaci capsaicinu o vysoké koncentraci u krys (cs)
  • Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application (en)
skos:notation
  • RIV/67985823:_____/06:00044589!RIV07-AV0-67985823
http://linked.open.../vavai/riv/strany
  • 233;243
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/06/1115), P(GA309/03/0752), P(GD305/03/H148), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 493318
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/06:00044589
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • capsaicin; TRPV1; surgical pain (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [DCACFDB4F39D]
http://linked.open...i/riv/nazevZdroje
  • Pain
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 125
http://linked.open...iv/tvurceVysledku
  • Pospíšilová, Eva
  • Paleček, Jiří
http://linked.open...n/vavai/riv/zamer
issn
  • 0304-3959
number of pages
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