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  • Genetic hypertension and other cardiovascular diseases might develop as a consequence of early errors in well-coordinated systems regulating cardiovascular homeostasis. If these early abnormalities in the ontogenetic cascade of expression of genetic information occur in critical periods of development (developmental windows), they can adversely modify subsequent development of the cardiovascular system. The consideration that hypertension and/or other cardiovascular diseases are late consequences of abnormal ontogeny of the cardiovascular system could explain why so many complex interactions among genes and environmental factors play such a significant role in the pathogenesis of these diseases
  • Genetic hypertension and other cardiovascular diseases might develop as a consequence of early errors in well-coordinated systems regulating cardiovascular homeostasis. If these early abnormalities in the ontogenetic cascade of expression of genetic information occur in critical periods of development (developmental windows), they can adversely modify subsequent development of the cardiovascular system. The consideration that hypertension and/or other cardiovascular diseases are late consequences of abnormal ontogeny of the cardiovascular system could explain why so many complex interactions among genes and environmental factors play such a significant role in the pathogenesis of these diseases (en)
  • Genetická hypertenze a jiné kardiovaskulární choroby vznikají jako důsledky časných poruch systémů regulujících kardiovaskulární homeostázu. Jestliže časné poruchy v kaskádě exprese genetické informace nastanou v některých kritických vývojových periodách, mohou nepříznivě ovlivnit následný vývoj kardiovaskulárního aparátu. To, že hypertenze a jiné kardiovaskulární choroby mohou být pozdními důsledky abnormálního vývoje kardiovaskulárního systému pomáhá vysvětlit, proč komplexní interakce mezi jednotlivými geny a faktory vnějšího prostředí hraje tak významnou úlohu v patogeneze těchto chorob (cs)
Title
  • Developmental windows and environment as important factors in the expression of genetic information: a cardiovascular physiologist's view
  • Developmental windows and environment as important factors in the expression of genetic information: a cardiovascular physiologist's view (en)
  • Vývojová okna a prostředí jako důležité faktory při expresi genetické informace: pohled kardiovaskulárního fyziologa (cs)
skos:prefLabel
  • Developmental windows and environment as important factors in the expression of genetic information: a cardiovascular physiologist's view
  • Developmental windows and environment as important factors in the expression of genetic information: a cardiovascular physiologist's view (en)
  • Vývojová okna a prostředí jako důležité faktory při expresi genetické informace: pohled kardiovaskulárního fyziologa (cs)
skos:notation
  • RIV/67985823:_____/06:00042825!RIV07-MZ0-67985823
http://linked.open.../vavai/riv/strany
  • 295;305
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR7786), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 471334
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/06:00042825
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • developmental window; genetic determinants; environmental stimuli (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [5634E6CE0373]
http://linked.open...i/riv/nazevZdroje
  • Clinical Science and Clinical Science and Molecular Medicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 111
http://linked.open...iv/tvurceVysledku
  • Kuneš, Jaroslav
  • Zicha, Josef
http://linked.open...n/vavai/riv/zamer
issn
  • 0143-5221
number of pages
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