About: Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining     Goto   Sponge   NotDistinct   Permalink

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Description
  • Blokáda muskarinových receptorů skopolaminem se používá jako model poruch paměti ve stáří. V předkládané studii jsme si položili otázku, jaký bude mít tato blokáda vliv na prostorovou orientaci u potkanů. Zjistili jsme, že aplikace skopolaminu vede k narušení orientace ve výše zmíněné úloze, ačkoliv dávky potřebné k této blokádě byly o něco vyšší než v předešlých studiích jiných autorů (cs)
  • In the present study we addressed whether navigation in the Active Allothetic Place Avoidance (AAPA) task, which requires animals to separate spatial stimuli into coherent representations and to navigate according to the representation relevant for the task, is dependent on intact muscarinic receptors in the brain. We studied the effect of three doses of scopolamine (0.5mg/kg, 1.0mg/kg and 2.0mg/kg) administered 20 min prior to training on the retention of the AAPA and re-acquisition of the AAPA in a new environment. The dose of 2.0 mg/kg was found to impair both AAPA retention and re-acquisition of the AAPA in a new environment, whereas the 1.0 mg/kg dose only impaired the reinforced retention of AAPA. It is concluded that, unlike navigation in classic paradigms, efficient orientation in the AAPA task is critically dependent on muscarinic receptors in the brain
  • In the present study we addressed whether navigation in the Active Allothetic Place Avoidance (AAPA) task, which requires animals to separate spatial stimuli into coherent representations and to navigate according to the representation relevant for the task, is dependent on intact muscarinic receptors in the brain. We studied the effect of three doses of scopolamine (0.5mg/kg, 1.0mg/kg and 2.0mg/kg) administered 20 min prior to training on the retention of the AAPA and re-acquisition of the AAPA in a new environment. The dose of 2.0 mg/kg was found to impair both AAPA retention and re-acquisition of the AAPA in a new environment, whereas the 1.0 mg/kg dose only impaired the reinforced retention of AAPA. It is concluded that, unlike navigation in classic paradigms, efficient orientation in the AAPA task is critically dependent on muscarinic receptors in the brain (en)
Title
  • Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining
  • Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining (en)
  • Centrální muskarinová blokáda poškozuje vybavení a znovunaučení aktivního alotetického vyhýbání se místu bez ohledu na intaktní předtrénování (cs)
skos:prefLabel
  • Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining
  • Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining (en)
  • Centrální muskarinová blokáda poškozuje vybavení a znovunaučení aktivního alotetického vyhýbání se místu bez ohledu na intaktní předtrénování (cs)
skos:notation
  • RIV/67985823:_____/05:00000814!RIV06-AV0-67985823
http://linked.open.../vavai/riv/strany
  • 238;244
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0517), P(GP309/03/P126), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 514634
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/05:00000814
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • place navigation; cognition; scopolamine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [E3A423D5EA33]
http://linked.open...i/riv/nazevZdroje
  • Behavioural Brain Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 161
http://linked.open...iv/tvurceVysledku
  • Stuchlík, Aleš
  • Valeš, Karel
http://linked.open...n/vavai/riv/zamer
issn
  • 0166-4328
number of pages
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