About: Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors

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About: Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We examined the dependence of P2XRs activity on ectodomain structure and agonist potency. Using rat P2X2aR, P2X2bR, P2X3R, and chimeras having the ectodomain sequences of P2X3R instead of ectodomain sequences of P2X2aR and P2X2bR we found that chimeric receptors inherited the P2X3R ligand-selective profile and desensitized with rates comparable to P2X2aR and P2X2bR. In striking contrast to parental receptors, the rates of decay in chimeric currents after agonist withdrawal were 15-200-fold slower We examined the dependence of P2XRs activity on ectodomain structure and agonist potency. Using rat P2X2aR, P2X2bR, P2X3R, and chimeras having the ectodomain sequences of P2X3R instead of ectodomain sequences of P2X2aR and P2X2bR we found that chimeric receptors inherited the P2X3R ligand-selective profile and desensitized with rates comparable to P2X2aR and P2X2bR. In striking contrast to parental receptors, the rates of decay in chimeric currents after agonist withdrawal were 15-200-fold slower (en) Zkoumali jsme závislost aktivity P2X receptorů na struktuře jejich ektodomény a na účinnosti různých agonistů. Pomocí P2X2aR, P2X2bR, P2X3R, a chimér, které měly sekvenci ektodomény P2X3R místo ectodomény P2X2aR a P2X2bR, jsme nalezli, že chimérní receptory mají P2X3R ligand-selektivní profil a desensitizují srovnatelně jako P2X2aR a P2X2bR. Na rozdíl od rodičovských receptorů byla deaktivace chimérních proudů 15-200-krát pomalejší (cs)
Title	Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors (en) Identifikace oblasti ektodomény, která hraje roli v aktivaci, deaktivaci a resensitizaci purinergních P2X receptorů (cs)
skos:prefLabel	Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors (en) Identifikace oblasti ektodomény, která hraje roli v aktivaci, deaktivaci a resensitizaci purinergních P2X receptorů (cs)
skos:notation	RIV/67985823:_____/04:00103108!RIV/2005/AV0/A20005/N
http://linked.open.../vavai/riv/strany	6968;6978
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	31
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Zemková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	567150
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/04:00103108
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purinergic receptors;gating;desensitization (en)
http://linked.open.../riv/klicoveSlovo	gating desensitization purinergic receptors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6CDC6E8F7B9E]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroscience
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Zemková, Hana Stojilkovic, S. S. He, M. L. Koshimizu, T.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0270-6474
number of pages	11 (xsd:int)

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