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Description
| - We examined the dependence of P2XRs activity on ectodomain structure and agonist potency. Using rat P2X2aR, P2X2bR, P2X3R, and chimeras having the ectodomain sequences of P2X3R instead of ectodomain sequences of P2X2aR and P2X2bR we found that chimeric receptors inherited the P2X3R ligand-selective profile and desensitized with rates comparable to P2X2aR and P2X2bR. In striking contrast to parental receptors, the rates of decay in chimeric currents after agonist withdrawal were 15-200-fold slower
- We examined the dependence of P2XRs activity on ectodomain structure and agonist potency. Using rat P2X2aR, P2X2bR, P2X3R, and chimeras having the ectodomain sequences of P2X3R instead of ectodomain sequences of P2X2aR and P2X2bR we found that chimeric receptors inherited the P2X3R ligand-selective profile and desensitized with rates comparable to P2X2aR and P2X2bR. In striking contrast to parental receptors, the rates of decay in chimeric currents after agonist withdrawal were 15-200-fold slower (en)
- Zkoumali jsme závislost aktivity P2X receptorů na struktuře jejich ektodomény a na účinnosti různých agonistů. Pomocí P2X2aR, P2X2bR, P2X3R, a chimér, které měly sekvenci ektodomény P2X3R místo ectodomény P2X2aR a P2X2bR, jsme nalezli, že chimérní receptory mají P2X3R ligand-selektivní profil a desensitizují srovnatelně jako P2X2aR a P2X2bR. Na rozdíl od rodičovských receptorů byla deaktivace chimérních proudů 15-200-krát pomalejší (cs)
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Title
| - Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors
- Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors (en)
- Identifikace oblasti ektodomény, která hraje roli v aktivaci, deaktivaci a resensitizaci purinergních P2X receptorů (cs)
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skos:prefLabel
| - Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors
- Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors (en)
- Identifikace oblasti ektodomény, která hraje roli v aktivaci, deaktivaci a resensitizaci purinergních P2X receptorů (cs)
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skos:notation
| - RIV/67985823:_____/04:00103108!RIV/2005/AV0/A20005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/04:00103108
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - purinergic receptors;gating;desensitization (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Zemková, Hana
- Stojilkovic, S. S.
- He, M. L.
- Koshimizu, T.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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