About: Rat model of familial combined hyperlipidemia as a result of comparative mapping

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	U 266 F 2 hybridů potkanů kmene Lewis a Pražského hypertriglyceridemického potkana (HTG), zvířat s řadou charakteristik lidského metabolického syndromu, byl skenován celkový genom. Výsledky ukazují na úzký vztah mezi dyslipidemií HTG potkanů a lidskou kombinovanou familiární hyperlipidemií a odhalují tak nový zvířecí model pro výzkum patofyziologie a léčby založené na znalostech genomu (cs) Total genome scan was carried out in 266 F2 hybrids of Lewis and Prague hypetriglyceridemic (HTG) rats which share some characteristics of human metabolic syndrome. Obtained data suggest a close relationship between dyslipidemia of HTG rats and human familial combined hyperlipidemia, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants Total genome scan was carried out in 266 F2 hybrids of Lewis and Prague hypetriglyceridemic (HTG) rats which share some characteristics of human metabolic syndrome. Obtained data suggest a close relationship between dyslipidemia of HTG rats and human familial combined hyperlipidemia, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants (en)
Title	Rat model of familial combined hyperlipidemia as a result of comparative mapping Rat model of familial combined hyperlipidemia as a result of comparative mapping (en) Potkaní (zvířecí) model kombinované familiární hyperlipidemie jako výsledek srovnávacího mapování (cs)
skos:prefLabel	Rat model of familial combined hyperlipidemia as a result of comparative mapping Rat model of familial combined hyperlipidemia as a result of comparative mapping (en) Potkaní (zvířecí) model kombinované familiární hyperlipidemie jako výsledek srovnávacího mapování (cs)
skos:notation	RIV/67985823:_____/04:00102584!RIV/2005/AV0/A20005/N
http://linked.open.../vavai/riv/strany	38;47
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/03/0769), P(IAA7011711), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Zicha, Josef Kuneš, Jaroslav Dobešová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	583579
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/04:00102584
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metabolic syndrome;Prague hypertriglyceridemic rat;quantitative trait locus (en)
http://linked.open.../riv/klicoveSlovo	quantitative trait locus metabolic syndrome Prague hypertriglyceridemic rat
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D18544C40AF9]
http://linked.open...i/riv/nazevZdroje	Physiological Genomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	The search for quantitative trait loci and candidate genes responsible for the pathogenesis of hypertension and metabolic syndrome Hypertension and Metabolic Syndrome: causes and consequences
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Kuneš, Jaroslav Zicha, Josef Sun, Y. Dobešová, Zdenka Hamet, P. Tremblay, J. Jacob, H. J. Pausová, Z. Deng, A. Y. Ueno, T.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	1094-8341
number of pages	10 (xsd:int)

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