About: Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity

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About: Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Odhalili jsme, že telmisartan, antagonista angiotensin II receptoru s ojedinělou strukturou, používaný k léčbě hypertenze, působí jako částečný agonista Pparg a ovlivňuje tak expresi cílových genů Pparg, regulujících metabolizmus uhlovodíků a tuků. U potkanů krmených dietou s vysokým obsahem tuků a uhlovodíků tak telmisartan snižuje hladiny glukózy, insulinu a triglyceridů (cs) We found that telmisartan, a structurally unique angiotensin II receptor antagonist used for the treatment of hypertension, can function as a partial agonist of the peroxisome proliferator activated receptor gamma (PPARgamma), influence the expression of PPARgamma target genes involved in carbohydrate and lipid metabolism, and reduce glucose, insulin, and triglyceride levels in rats fed a high fat, high carbohydrate diet We found that telmisartan, a structurally unique angiotensin II receptor antagonist used for the treatment of hypertension, can function as a partial agonist of the peroxisome proliferator activated receptor gamma (PPARgamma), influence the expression of PPARgamma target genes involved in carbohydrate and lipid metabolism, and reduce glucose, insulin, and triglyceride levels in rats fed a high fat, high carbohydrate diet (en)
Title	Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity Odhalení telmisartanu jako unikátního antagonisty angiotensin II receptoru se selektivní modulační aktivitou Pparg (cs) Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity (en)
skos:prefLabel	Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity Odhalení telmisartanu jako unikátního antagonisty angiotensin II receptoru se selektivní modulační aktivitou Pparg (cs) Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity (en)
skos:notation	RIV/67985823:_____/04:00102560!RIV/2005/AV0/A20005/N
http://linked.open.../vavai/riv/strany	993;1002
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/01/0278), P(LN00A079), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Pravenec, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	567184
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/04:00102560
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	receptors;insulin resistance;losartan (en)
http://linked.open.../riv/klicoveSlovo	receptors insulin resistance losartan
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[46A406D05CE9]
http://linked.open...i/riv/nazevZdroje	Hypertension
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Cardiovascular risk factors cluster analyzed by transgenesis of the peroxisome proliferatoractivated receptor gamma Center of Integrated Genomics
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Kurtz, T. W. Pravenec, Michal Wang, J. Qi, N. Pershadsingh, H. A. Avery, M. A. Benson, S. C. Chittiboyina, A. Desai, P. Ho, C. I.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0194-911X
number of pages	10 (xsd:int)

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