About: Effect of thyroid hormones on the gene expression of calcium transport systems in rat muscles

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hypertyroidní stav byl navozen injekcí trijodtyroninu, hypotyroidní stav byl navozen pomocí methimazolu. Zjistili jsme, že po 2 až 10 měsících aplikace T3 došlo k statisticky významnému vzestupu úrovně mRNA u NCX, RyRs a IP3 receptorů. Tento vzestup byl výraznější v pomalém svalu m. soleus než v rychlém EDL svalu. Výsledky naznačují, že tyroidní hormony by tak přes změnu koncentrace vápníku mohly ovlivňovat i proces spojení excitace a kontrakce v kosterních svalech (cs) A hyperthyroid state was maintained in rats by triiodothyronine (T3) administration, while methimazole was employed for inducing hypothyroidism. After a period of 2-10 months of T3 treatment we observed a significant increase in mRNA levels of the NCX, RyRs and IP3 receptors. This increase was more pronounced in the slow soleus than in the fast EDL muscle. It is tempting to speculate that thyroid hormones also alter calcium concentration and thus influence the process of excitation-contraction coupling in the skeletal muscle A hyperthyroid state was maintained in rats by triiodothyronine (T3) administration, while methimazole was employed for inducing hypothyroidism. After a period of 2-10 months of T3 treatment we observed a significant increase in mRNA levels of the NCX, RyRs and IP3 receptors. This increase was more pronounced in the slow soleus than in the fast EDL muscle. It is tempting to speculate that thyroid hormones also alter calcium concentration and thus influence the process of excitation-contraction coupling in the skeletal muscle (en)
Title	Effect of thyroid hormones on the gene expression of calcium transport systems in rat muscles Effect of thyroid hormones on the gene expression of calcium transport systems in rat muscles (en) Působení tyroidních hormonů na expresi vápník transportujících systémů ve svalech potkana (cs)
skos:prefLabel	Effect of thyroid hormones on the gene expression of calcium transport systems in rat muscles Effect of thyroid hormones on the gene expression of calcium transport systems in rat muscles (en) Působení tyroidních hormonů na expresi vápník transportujících systémů ve svalech potkana (cs)
skos:notation	RIV/67985823:_____/04:00102545!RIV/2005/AV0/A20005/N
http://linked.open.../vavai/riv/strany	923;931
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/03/0752), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Vadászová, Adriana Soukup, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	562077
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/04:00102545
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	thyroid hormones;calcium transport systems (en)
http://linked.open.../riv/klicoveSlovo	thyroid hormones calcium transport systems
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[349224526F10]
http://linked.open...i/riv/nazevZdroje	Life Sciences
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular and molecular mechanisms of nociception at spinal cord level.
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Soukup, Tomáš Križanová, O. Vadászová, Adriana Hudecová, S.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0024-3205
number of pages	9 (xsd:int)

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