About: Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors.

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About: Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The transformed C6 glial cells in cultures were treated with sodium mercaptoborate (Na2B12H11SH, BSH), a carrier of atomic targets (10B) of thermal neutrons for the Neutron Capture Therapy (NCT) of brain tumors. The therapeutic dose of BSH (100 micro g/ml) did not alter gross morphology and growth of the population of cells while activation of nucleoli and enlargment of mitochondria was revelaed by electron microscopy. After 200 micro g BSH/ml cell population growth was inhibited, the nuclear chromatin was more condensed and allocated to the nuclear envelope which formed deeper invaginations. Mitochondria further increased in size and the circumscribed segments their cristae disappeared or were reduced to fine pouch-like structures near the continuous outer membrane, suggestive for a non-destructive restructuring of the inner mitochondrial membrane. The smooth pinocytotic vesicles near the plasma membrane, lysosomes and heterogeneous dense bodies were more frequent. The revealed subcellular targets The transformed C6 glial cells in cultures were treated with sodium mercaptoborate (Na2B12H11SH, BSH), a carrier of atomic targets (10B) of thermal neutrons for the Neutron Capture Therapy (NCT) of brain tumors. The therapeutic dose of BSH (100 micro g/ml) did not alter gross morphology and growth of the population of cells while activation of nucleoli and enlargment of mitochondria was revelaed by electron microscopy. After 200 micro g BSH/ml cell population growth was inhibited, the nuclear chromatin was more condensed and allocated to the nuclear envelope which formed deeper invaginations. Mitochondria further increased in size and the circumscribed segments their cristae disappeared or were reduced to fine pouch-like structures near the continuous outer membrane, suggestive for a non-destructive restructuring of the inner mitochondrial membrane. The smooth pinocytotic vesicles near the plasma membrane, lysosomes and heterogeneous dense bodies were more frequent. The revealed subcellular targets (en)
Title	Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors. Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors. (en)
skos:prefLabel	Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors. Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors. (en)
skos:notation	RIV/67985823:_____/03:20030105!RIV/2004/AV0/A20004/N
http://linked.open.../vavai/riv/strany	629;635
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(FD-K/048), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Mareš, Vladislav Lisá, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	629647
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/03:20030105
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	thermal neutrons; brain tumors; sodium borocaptate (en)
http://linked.open.../riv/klicoveSlovo	thermal neutrons sodium borocaptate brain tumors
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F2D1EF3205D6]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Research and development of techniques and equipments for application of ionising radiation in industry and human medicine.
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Krajčí, D. Lisá, Věra Mareš, Vladislav
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0862-8408
number of pages	7 (xsd:int)

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