About: Cisplatin induced gamma-glutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture.

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About: Cisplatin induced gamma-glutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	C6 glioma cells in culture treated with Cisplatin (1.6 x 10-5M) inhibited cell division and later about half of the population underwent apoptosis. The more resistant and surviving cells became hypertrophic and more differentiated. Activity of gamma-glutamyltransferase (GGT) was significantly elevated at 48 h and onwards. Compared to the protein content, the GGT activity started to increase later (48 h) but it grew steeper towards 72-96 h. Histochemical analysis revealed a manifold increase in the number of GGT+ cells in the population and higher intensity of staining per cell from at 48 h and onwards. The study showed that the transformed astrocytic cells can up-can regulate GGT activity as part of an adaptation and/or, survival-enhancing reaction triggered by Cisplatin. C6 glioma cells in culture treated with Cisplatin (1.6 x 10-5M) inhibited cell division and later about half of the population underwent apoptosis. The more resistant and surviving cells became hypertrophic and more differentiated. Activity of gamma-glutamyltransferase (GGT) was significantly elevated at 48 h and onwards. Compared to the protein content, the GGT activity started to increase later (48 h) but it grew steeper towards 72-96 h. Histochemical analysis revealed a manifold increase in the number of GGT+ cells in the population and higher intensity of staining per cell from at 48 h and onwards. The study showed that the transformed astrocytic cells can up-can regulate GGT activity as part of an adaptation and/or, survival-enhancing reaction triggered by Cisplatin. (en)
Title	Cisplatin induced gamma-glutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture. Cisplatin induced gamma-glutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture. (en)
skos:prefLabel	Cisplatin induced gamma-glutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture. Cisplatin induced gamma-glutamyltransferase up-regulation, hypertrophy and differentiation in astrocytic glioma cells in culture. (en)
skos:notation	RIV/67985823:_____/03:20030088!RIV/2004/GA0/A20004/N
http://linked.open.../vavai/riv/strany	687;693
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/02/0962), Z(AV0Z5011922), Z(AV0Z5020903)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Mareš, Vladislav Lisá, Věra Malík, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	601301
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/03:20030088
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glioma; cisplatin; gamma-glutamytranspeptidase (en)
http://linked.open.../riv/klicoveSlovo	glioma gamma-glutamytranspeptidase cisplatin
http://linked.open...odStatuVydavatele	ES - Španělské království
http://linked.open...ontrolniKodProRIV	[7C6CB6387F82]
http://linked.open...i/riv/nazevZdroje	Histology and Histopathology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of Dipeptidyl Peptidase IV-like Molecules in the Regulation of Growth Properties of Transformed Neuroectodermal Cells
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Lisá, Věra Mareš, Vladislav Kozáková, Hana Šedo, A. Malík, Radek
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů
issn	0213-3911
number of pages	7 (xsd:int)

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