About: Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains.

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About: Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Low-density membrane fragments (domains) were separated from the bulk plasma membranes of HEK293 cells expressing DOP receptor-Gi1alpha fusion protein by drastic homogenization and flotation on sucrose density gradient. Low-density domains exhibited four times higher agonist-stimulated GTPase activity and GTPgammaS binding than the bulk plasma membranes (when corrected for expression levels of the receptor). RGS1 enhanced further the G protein functional activity but did not remove the difference between domain-bound and plasma membrane pools of G protein. By contrast, detergent-extraction of membrane domains diminished functional coupling between G proteinůcoupled receptor and corresponding G protein. Low-density membrane fragments (domains) were separated from the bulk plasma membranes of HEK293 cells expressing DOP receptor-Gi1alpha fusion protein by drastic homogenization and flotation on sucrose density gradient. Low-density domains exhibited four times higher agonist-stimulated GTPase activity and GTPgammaS binding than the bulk plasma membranes (when corrected for expression levels of the receptor). RGS1 enhanced further the G protein functional activity but did not remove the difference between domain-bound and plasma membrane pools of G protein. By contrast, detergent-extraction of membrane domains diminished functional coupling between G proteinůcoupled receptor and corresponding G protein. (en)
Title	Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. (en)
skos:prefLabel	Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. (en)
skos:notation	RIV/67985823:_____/03:20030014!RIV/2004/MSM/A20004/N
http://linked.open.../vavai/riv/strany	34;49
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/01/0255), P(LN00A026), Z(AV0Z5011922), Z(MSM 113100003)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Koštrnová, Alexandra Svoboda, Petr Moravcová, Zuzana Roubalová, Lenka Hejnová, Lucie Novotný, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	603023
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/03:20030014
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	membrane domains; GTPase activity; G protein coupling (en)
http://linked.open.../riv/klicoveSlovo	membrane domains G protein coupling GTPase activity
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1ED3B5F0F943]
http://linked.open...i/riv/nazevZdroje	Journal of Neurochemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology The role subcellular redistribution of trimeric G proteins in mechanism of hormone action and desensitisation
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Novotný, Jiří Svoboda, Petr Hejnová, Lucie Bouřová, Lenka Moravcová, Zuzana Milligan, G. Koštrnová, Alexandra Moon, H. E.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100003
issn	0022-3042
number of pages	16 (xsd:int)

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