About: Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus.

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About: Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ontogenetic changes in the levels of GABAB receptors and their ability to modulate adenylyl cyclase (AC) activity were analyzed in rat cortex, thalamus and hippocampus. Our data indicate that the inhibitory effect of baclofen on AC in cortex and thalamus is primarily mediated through the alpha subunits of Gi/Go proteins. The stimulatory effect of baclofen in hippocampus may be explained by engagenement of Gbetagamma-subunits. Ontogenetic changes in the levels of GABAB receptors and their ability to modulate adenylyl cyclase (AC) activity were analyzed in rat cortex, thalamus and hippocampus. Our data indicate that the inhibitory effect of baclofen on AC in cortex and thalamus is primarily mediated through the alpha subunits of Gi/Go proteins. The stimulatory effect of baclofen in hippocampus may be explained by engagenement of Gbetagamma-subunits. (en)
Title	Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus. Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus. (en)
skos:prefLabel	Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus. Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus. (en)
skos:notation	RIV/67985823:_____/02:20020077!RIV/2003/GA0/A20003/N
http://linked.open.../vavai/riv/strany	9;12
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/01/0255), P(GA309/99/0207), P(LN00A026), Z(AV0Z5011922), Z(MSM 113100003)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Ihnatovych, Ivanna Mareš, Pavel Svoboda, Petr Kubová, Hana Hejnová, Lucie Novotný, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	654051
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/02:20020077
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GABA(B) receptors; baclofen; adenylyl cyclase (en)
http://linked.open.../riv/klicoveSlovo	GABA(B) receptors adenylyl cyclase baclofen
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[27ED946149F2]
http://linked.open...i/riv/nazevZdroje	Neuroscience Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology The role subcellular redistribution of trimeric G proteins in mechanism of hormone action and desensitisation Does the receptor, spectrum of G proteins and the role of GABA-B system change during development
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	330
http://linked.open...iv/tvurceVysledku	Mareš, Pavel Novotný, Jiří Svoboda, Petr Kubová, Hana Hejnová, Lucie Ihnatovych, Ivanna
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100003
issn	0304-3940
number of pages	4 (xsd:int)

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