About: Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats.

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About: Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Adaptation of rats to chronic hypoxia increases the tolerance of their hearts to acute ischemia/reperfusion injury. Administration of a selective blocker of mitochondrial ATP sensitive potassium channels (KATP) 5-hydroxydecanoate abolished cardioprotective effects of chronic hypoxia; administration of selective KATP channels openers (diazoxide and BMS 191095) induced protection in normoxic hearts and but did not influence hypoxic heart. The results suggest that opening of mitochondrial KATP channels is involved in the cardioprotective mechanism conferred by long-term adaptation to chronic hypoxia. Adaptation of rats to chronic hypoxia increases the tolerance of their hearts to acute ischemia/reperfusion injury. Administration of a selective blocker of mitochondrial ATP sensitive potassium channels (KATP) 5-hydroxydecanoate abolished cardioprotective effects of chronic hypoxia; administration of selective KATP channels openers (diazoxide and BMS 191095) induced protection in normoxic hearts and but did not influence hypoxic heart. The results suggest that opening of mitochondrial KATP channels is involved in the cardioprotective mechanism conferred by long-term adaptation to chronic hypoxia. (en)
Title	Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. (en)
skos:prefLabel	Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. (en)
skos:notation	RIV/67985823:_____/02:20020057!RIV/2003/GA0/A20003/N
http://linked.open.../vavai/riv/strany	567;575
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/01/0279), P(GA306/98/0470), P(LN00A069), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Szárszoi, Ondrej Papoušek, František Kolář, František Ošťádal, Bohuslav Neckář, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	644433
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/02:20020057
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	contractile function; hypoxia/anoxia; K-ATP channel (en)
http://linked.open.../riv/klicoveSlovo	contractile function K-ATP channel hypoxia/anoxia
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[E0AFAF37E32B]
http://linked.open...i/riv/nazevZdroje	Cardiovascular Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of increased ischaemic tolerance in chronically hypoxic heart Center for experimental research of cardiovascular diseases Cardioprotective mechanisms of adaptation to chronic hypoxia: relation to preconditioning
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Neckář, Jan Szárszoi, Ondrej Kolář, František Papoušek, František Ošťádal, Bohuslav Grover, G. J. Koten, L.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0008-6363
number of pages	9 (xsd:int)

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