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| rdf:type
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| Description
| - Imunitní modulační terapie (IMT) firmy Vasogen je terapie, při které jsou krevní buňky pacienta modifikovány ex vivo pomocí fyzikochemických stresorů zahrnujících oxidaci, UV záření a zvýšenou teplotu. Studie testovala hypotézu, že IMT může zabránit ischemicko-reperfuznímu (I/R) poškození ledvin u potkanů. Aplikace metody u SHR potkanů významně snížila I/R poškození v porovnání se zvířaty u nichž byla podána neupravená krev a nebo fyziologický roztok. To bylo evidentní na zvýšení přežívání u mladých i dospělých SHR potkanů, což korelovalo s 24 hod. diurézou. Naše výsledky ukázaly, že IMT zabrání destrukci ledvinné tkáně a tím sníží úmrtnost na I/R poškození ledvin (cs)
- Vasogen Inc.'s immune modulation therapy (IMT) is a therapy in which cells from the patient's own blood are modified by ex vivo exposure to specific physicochemical stressors, including oxidation, ultraviolet (UV) light, and an elevated temperature. This study tested the hypothesis that IMT can prevent renal ischemia-reperfusion (I/R) injury in rats. IMT pretreatment of SHR significantly reduced renal I/R injury compared with equivalent placebo treatments consisting of untreated blood- or saline-injected SHR, as evidenced by a significant increase of the survival rate curves in young and old male SHR, which correlated with 24-hour postischemic diuresis. Our data demonstrate that IMT prevents the destruction of kidney tissue and the resulting animal death caused by renal I/R injury
- Vasogen Inc.'s immune modulation therapy (IMT) is a therapy in which cells from the patient's own blood are modified by ex vivo exposure to specific physicochemical stressors, including oxidation, ultraviolet (UV) light, and an elevated temperature. This study tested the hypothesis that IMT can prevent renal ischemia-reperfusion (I/R) injury in rats. IMT pretreatment of SHR significantly reduced renal I/R injury compared with equivalent placebo treatments consisting of untreated blood- or saline-injected SHR, as evidenced by a significant increase of the survival rate curves in young and old male SHR, which correlated with 24-hour postischemic diuresis. Our data demonstrate that IMT prevents the destruction of kidney tissue and the resulting animal death caused by renal I/R injury (en)
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| Title
| - Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy
- Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy (en)
- Renálnímu ischemickoreperfuzní poškození může být zabráněno novou imunomodulační terapií (cs)
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| skos:prefLabel
| - Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy
- Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy (en)
- Renálnímu ischemickoreperfuzní poškození může být zabráněno novou imunomodulační terapií (cs)
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| skos:notation
| - RIV/67985823:_____/02:00142385!RIV07-AV0-67985823
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/02:00142385
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - renal ischemia; immune therapy; rat (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Chen, H.
- Kuneš, Jaroslav
- Peng, J.
- Hamet, P.
- Tremblay, J.
- deBlois, D.
- Bolton, A. E.
- Der Sarkissian, S.
- Gaboury, L.
- Gouadon, E.
- Marshansky, V.
- Vu, M. D.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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