About: Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction.

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About: Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60 and the temperature dependence was negligible. However, an inverse temperature dependence was found when low concentrations 3 x 10(-7) and 6 x 10(-7) M were applied. The depression of f was 40-50 in 5-10 degrees C but only 10-20 of the control in the 25 and 30 degrees C. During application of CCh, the new steady of f was reached at temperatures between 5 and 30 degrees C within 17-20 min (Q10 = 1.07). Much greater temperature dependence of recovery was observed during washing out CCh (Q10 = 1.6). The temperature-independence of the steady state effects of CCh, good agreement with Langmuir adsorption-desorption theory and non-steady kinetics indicate that physical rather than receptor-mediated events are responsible for the depression of f. The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60 and the temperature dependence was negligible. However, an inverse temperature dependence was found when low concentrations 3 x 10(-7) and 6 x 10(-7) M were applied. The depression of f was 40-50 in 5-10 degrees C but only 10-20 of the control in the 25 and 30 degrees C. During application of CCh, the new steady of f was reached at temperatures between 5 and 30 degrees C within 17-20 min (Q10 = 1.07). Much greater temperature dependence of recovery was observed during washing out CCh (Q10 = 1.6). The temperature-independence of the steady state effects of CCh, good agreement with Langmuir adsorption-desorption theory and non-steady kinetics indicate that physical rather than receptor-mediated events are responsible for the depression of f. (en)
Title	Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction. Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction. (en)
skos:prefLabel	Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction. Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction. (en)
skos:notation	RIV/67985823:_____/01:20010333!RIV/2004/MSM/A20004/N
http://linked.open.../vavai/riv/strany	891;897
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA7011902), P(OK 267), Z(AV0Z5011922), Z(MSM 113100003)
http://linked.open...iv/cisloPeriodika	8-9
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Vyskočil, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	698426
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010333
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carbachol; - temperature; - acetylcholine release (en)
http://linked.open.../riv/klicoveSlovo	- acetylcholine release - temperature carbachol
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B1FB729A6CBE]
http://linked.open...i/riv/nazevZdroje	Neurochemical Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OK%20267 The structure and function of the nicotinic acetylcholine receptor
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Vyskočil, František Nikolsky, E. E. Borisover, M. D. Strunsky, E. G.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100003
issn	0364-3190
number of pages	7 (xsd:int)

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