About: Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels.

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About: Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated whether amyloid- -peptide (A 1-42) has an effect on the elevations of the intracellular concentration of Ca2+ ions ([Ca2+]i ) induced by depolarizations of NG108-15 cells and on related Ca2+ channels. A 1-42 (10 - 1000 nM) had no immediate effect on depolarization-induced [Ca2+]i elevations. [Ca2+]i increases were slightly diminished in cells grown in the presence of 100 or 1000 nM A 1-42. Nifedipine (1 M) reduced these elevations equally in cells grown in the absence or presence of A 1-42. In contrast, the ability of ?-conotoxin GVIA to diminish the depolarization-induced [Ca2+]i responses became lost in cells grown in the presence of 100 nM A 1-42. This indicates that the influx of calcium through the N-type Ca2+ channels was compromised by the chronic exposure of cells to a submicromolar concentration of A 1-42 , presumably because of impairement of their function or diminished expression. This may be important in the pathogeny of Alzheimer s dementia in view of the pivotal role o We investigated whether amyloid- -peptide (A 1-42) has an effect on the elevations of the intracellular concentration of Ca2+ ions ([Ca2+]i ) induced by depolarizations of NG108-15 cells and on related Ca2+ channels. A 1-42 (10 - 1000 nM) had no immediate effect on depolarization-induced [Ca2+]i elevations. [Ca2+]i increases were slightly diminished in cells grown in the presence of 100 or 1000 nM A 1-42. Nifedipine (1 M) reduced these elevations equally in cells grown in the absence or presence of A 1-42. In contrast, the ability of ?-conotoxin GVIA to diminish the depolarization-induced [Ca2+]i responses became lost in cells grown in the presence of 100 nM A 1-42. This indicates that the influx of calcium through the N-type Ca2+ channels was compromised by the chronic exposure of cells to a submicromolar concentration of A 1-42 , presumably because of impairement of their function or diminished expression. This may be important in the pathogeny of Alzheimer s dementia in view of the pivotal role o (en)
Title	Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels. Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels. (en)
skos:prefLabel	Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels. Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels. (en)
skos:notation	RIV/67985823:_____/01:20010276!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	1079;1084
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NF5183), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	8-9
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Tuček, Stanislav Nováková, Jana Doležal, Vladimír Lisá, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	675629
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010276
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amyloid beta peptide; - Alzheimer's disease; - calcium (en)
http://linked.open.../riv/klicoveSlovo	amyloid beta peptide - calcium - Alzheimer's disease
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[58648ECEF632]
http://linked.open...i/riv/nazevZdroje	Neurochemical Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of beta-amyloid on the function of cholinergic synapses.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Lisá, Věra Kašparová, Jana Doležal, Vladimír Tuček, Stanislav
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0364-3190
number of pages	6 (xsd:int)

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