About: Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein.

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About: Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We searched for the previously defined uncoupling protein (UCP) signatures [Je'ek P. and Urb nkov , E. (2000) IUBMB Life 49, 63-70] in genomes of Drosophila melanogaster, Caenorhabditis elegans, Dictyostelium discoideum, and Arabidopsis thaliana. We identified four UCPs in Drosophila and one in Caenorhabditis or Dictyostelium as close relatives of human UCP4 (BMCP), but distant from UCP1, UCP2, UCP3, and two plant UCPs of Arabidopsis. But the third Arabidopsis UCP is the closest UCP4 relative. This suggests that UCP4 represents the ancestral UCP form from which other mammalian and plat UCPs diverged. It is surprising in the light of the fact that in humans UCP4 is brain-specific protein. Speculations on UCP4 participation in apoptosis are thus supported by its early phylogenetic occurrence. We searched for the previously defined uncoupling protein (UCP) signatures [Je'ek P. and Urb nkov , E. (2000) IUBMB Life 49, 63-70] in genomes of Drosophila melanogaster, Caenorhabditis elegans, Dictyostelium discoideum, and Arabidopsis thaliana. We identified four UCPs in Drosophila and one in Caenorhabditis or Dictyostelium as close relatives of human UCP4 (BMCP), but distant from UCP1, UCP2, UCP3, and two plant UCPs of Arabidopsis. But the third Arabidopsis UCP is the closest UCP4 relative. This suggests that UCP4 represents the ancestral UCP form from which other mammalian and plat UCPs diverged. It is surprising in the light of the fact that in humans UCP4 is brain-specific protein. Speculations on UCP4 participation in apoptosis are thus supported by its early phylogenetic occurrence. (en)
Title	Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein. Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein. (en)
skos:prefLabel	Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein. Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein. (en)
skos:notation	RIV/67985823:_____/01:20010256!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	137;141
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/98/0568), P(IAA5011106), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Ježek, Petr Hanák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	687104
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010256
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	phylogenesis of mitochondrial uncoupling protein; - specific sequence motif (en)
http://linked.open.../riv/klicoveSlovo	- specific sequence motif phylogenesis of mitochondrial uncoupling protein
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B9A765E6293C]
http://linked.open...i/riv/nazevZdroje	FEBS Letters
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular biology and structure funcition studies of multiple substitution mutants of mitochondrial uncoupling protein Studies of novel mitochondrial uncoupling proteins
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	495
http://linked.open...iv/tvurceVysledku	Ježek, Petr Hanák, Petr
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0014-5793
number of pages	5 (xsd:int)

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