About: A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture.

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About: A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We examined the impact of gender of rat donors on the degree of hyperplastic and hypertrophic responses of vascular smooth muscle cells (VSMC) in cultures subjected to repeated passaging. At pasages 40-45, the hyperplastic response, monitored by doubling time and BrdU-revealed DNA synthesis, was more intense in VSMC of male origin. Female VSMC reacted by more prominent hypertrophic changes, including increase in the volume and protein content as well as polyploidization. In addition, these cells were more effective in adhesion to the growth support (wider spreading, higher content and organization of alpha v integrin and vinculin molecules). The lower responsiveness of female-derived cells to growth stimuli may contribute to less frequent formation of hyperplastic vascular lesions in female organisms. We examined the impact of gender of rat donors on the degree of hyperplastic and hypertrophic responses of vascular smooth muscle cells (VSMC) in cultures subjected to repeated passaging. At pasages 40-45, the hyperplastic response, monitored by doubling time and BrdU-revealed DNA synthesis, was more intense in VSMC of male origin. Female VSMC reacted by more prominent hypertrophic changes, including increase in the volume and protein content as well as polyploidization. In addition, these cells were more effective in adhesion to the growth support (wider spreading, higher content and organization of alpha v integrin and vinculin molecules). The lower responsiveness of female-derived cells to growth stimuli may contribute to less frequent formation of hyperplastic vascular lesions in female organisms. (en)
Title	A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture. A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture. (en)
skos:prefLabel	A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture. A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture. (en)
skos:notation	RIV/67985823:_____/01:20010201!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	675;684
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA7011908), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Bačáková, Lucie Mareš, Vladislav Lisá, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	672322
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010201
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	rat aortic smooth muscle cells; - polyploidization; - gender differences (en)
http://linked.open.../riv/klicoveSlovo	- gender differences - polyploidization rat aortic smooth muscle cells
http://linked.open...odStatuVydavatele	ES - Španělské království
http://linked.open...ontrolniKodProRIV	[EB30BF4AFEEA]
http://linked.open...i/riv/nazevZdroje	Histology and Histopathology
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Improved cell adhesion on physico-chemically modified polymer surfaces
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Bačáková, Lucie Lisá, Věra Mareš, Vladislav Pellicciari, C. Bottone, M. G.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0213-3911
number of pages	10 (xsd:int)

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