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rdf:type
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Description
| - A new comparative characteristic of endplate microphysiology has been introduced. It is the feasibility of receptors to become desensitised as demonstrated on two frog species, Rana temporaria and Rana ridibunda: the decay times (tau(MEPC)) of single quantum miniature endplate currents (MEPCs) in the sartorius muscles of both species were about 1 ms and were not affected by the desensitisation-promoting agent proadifen when AChE was active. However, when the desensitisation was induced by anticholinesterase neostigmine and promoted by proadifen, the prolongation of tau(MEPC) from 1 ms was almost twice as great in Rana temporaria (tau(MEPC) = 4.4 ms) than in Rana ridibunda (tau(MEPC) = 3.1). This indicates that desensitisation reduces the number of available receptors and lowers the number of available ACh molecules for repetitive binding by trapping them by desensitised, high-affinity receptors significantly more in Rana ridibunda than in Rana temporaria. The application of proadifen, a promoter of de
- A new comparative characteristic of endplate microphysiology has been introduced. It is the feasibility of receptors to become desensitised as demonstrated on two frog species, Rana temporaria and Rana ridibunda: the decay times (tau(MEPC)) of single quantum miniature endplate currents (MEPCs) in the sartorius muscles of both species were about 1 ms and were not affected by the desensitisation-promoting agent proadifen when AChE was active. However, when the desensitisation was induced by anticholinesterase neostigmine and promoted by proadifen, the prolongation of tau(MEPC) from 1 ms was almost twice as great in Rana temporaria (tau(MEPC) = 4.4 ms) than in Rana ridibunda (tau(MEPC) = 3.1). This indicates that desensitisation reduces the number of available receptors and lowers the number of available ACh molecules for repetitive binding by trapping them by desensitised, high-affinity receptors significantly more in Rana ridibunda than in Rana temporaria. The application of proadifen, a promoter of de (en)
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Title
| - The role of desensititation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria.
- The role of desensititation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria. (en)
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skos:prefLabel
| - The role of desensititation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria.
- The role of desensititation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria. (en)
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skos:notation
| - RIV/67985823:_____/01:20010193!RIV/2004/MSM/A20004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(IAA7011902), P(OK 267), P(VS97099), Z(AV0Z5011922)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/01:20010193
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - frog; - desensitisation; - miniature endplate potential (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Vyskočil, František
- Giniatullin, R. A.
- Talantova, M. V.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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