About: Differentiation of NG108-15 cells induced by the combined presence of dbcAMP and dexamethasone brings about the expression of N and P/Q types of calcium channels and the inhibitory influence of muscarinic receptors on calcium influx.

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About: Differentiation of NG108-15 cells induced by the combined presence of dbcAMP and dexamethasone brings about the expression of N and P/Q types of calcium channels and the inhibitory influence of muscarinic receptors on calcium influx. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Differentiation of cholinergic cell line NG108-15 induced by a combination of dibutyryl cyclic AMP (dbcAMP) and dexamethasone enhances the cholinergic phenotype of the cells more than that induced by either agent alone. We investigated the effect of treatment with dbcAMP and dexamethasone on potassium depolarization-evoked influx of calcium and its regulation by the muscarinic agonist carbachol. Depolarization of control cells and of cells differentiated in the presence of dbcAMP or dexamethasone alone, or in the combined presence of dbcAMP and dexamethasone induced, respectively, 2.2, 4.3, 2.7 and 10.7 fold increases of the resting [Ca2+]i. Dexamethasone alone and the combination of dbcAMP and dexamethasone augmented the number of muscarinic receptors by 25 and 40, respectively. Inhibitors of N ((-conotoxin GVIA) or P/Q ((-agatoxin TK) calcium channels had no effect on Ca2+ influx in control cells whereas in cells differentiated in the combined presence of dbcAMP and dexamethasone they significantly Differentiation of cholinergic cell line NG108-15 induced by a combination of dibutyryl cyclic AMP (dbcAMP) and dexamethasone enhances the cholinergic phenotype of the cells more than that induced by either agent alone. We investigated the effect of treatment with dbcAMP and dexamethasone on potassium depolarization-evoked influx of calcium and its regulation by the muscarinic agonist carbachol. Depolarization of control cells and of cells differentiated in the presence of dbcAMP or dexamethasone alone, or in the combined presence of dbcAMP and dexamethasone induced, respectively, 2.2, 4.3, 2.7 and 10.7 fold increases of the resting [Ca2+]i. Dexamethasone alone and the combination of dbcAMP and dexamethasone augmented the number of muscarinic receptors by 25 and 40, respectively. Inhibitors of N ((-conotoxin GVIA) or P/Q ((-agatoxin TK) calcium channels had no effect on Ca2+ influx in control cells whereas in cells differentiated in the combined presence of dbcAMP and dexamethasone they significantly (en)
Title	Differentiation of NG108-15 cells induced by the combined presence of dbcAMP and dexamethasone brings about the expression of N and P/Q types of calcium channels and the inhibitory influence of muscarinic receptors on calcium influx. Differentiation of NG108-15 cells induced by the combined presence of dbcAMP and dexamethasone brings about the expression of N and P/Q types of calcium channels and the inhibitory influence of muscarinic receptors on calcium influx. (en)
skos:prefLabel	Differentiation of NG108-15 cells induced by the combined presence of dbcAMP and dexamethasone brings about the expression of N and P/Q types of calcium channels and the inhibitory influence of muscarinic receptors on calcium influx. Differentiation of NG108-15 cells induced by the combined presence of dbcAMP and dexamethasone brings about the expression of N and P/Q types of calcium channels and the inhibitory influence of muscarinic receptors on calcium influx. (en)
skos:notation	RIV/67985823:_____/01:20010190!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	134;141
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/01/0283), P(GA305/98/0469), P(NF5183), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Tuček, Stanislav Nováková, Jana Doležal, Vladimír Lisá, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	677766
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010190
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NG108-15 cell line; - cAMP; - calcium channels (en)
http://linked.open.../riv/klicoveSlovo	- cAMP - calcium channels NG108-15 cell line
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[A04FE2FD090E]
http://linked.open...i/riv/nazevZdroje	Brain Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Plasticity of cholinergic neurotransmission Mechanism and possibilities of pharmacological intervention in presynaptic regulation of acetycholine release Effects of beta-amyloid on the function of cholinergic synapses.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	910
http://linked.open...iv/tvurceVysledku	Lisá, Věra Kašparová, Jana Doležal, Vladimír Tuček, Stanislav Diebler, M. F.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0006-8993
number of pages	8 (xsd:int)

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