About: Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats.

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About: Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The objective of this study was to compare the gene expression of individual components of the renin-angiotensin system (RAS) in hearts of normotensive and hypertensive rats. Two genetically hypertensive rat strains - spontaneously hypertensive rats (SHR) and hereditary hypertriglyceridemic rats (HTG) - were compared with Wistar-Kyoto (WKY) and Lewis (LEW) normotensive controls. In addition, developmental changes in gene expression of individual components of cardiac RAS were studied in 20-day-old fetuses, 2-day-old newborns and 3-month-old HTG and LEW rats. Angiotensinogen gene expression did not differ either among adult normotensive and hypertensive strains, or during development. The renin gene expression was significantly increased in hypertensive heart when compared to normotensive one. There was also an age-dependent increase of ACE gene expression in both HTG and LEW rats, which was delayed in HTG hearts. Results suggest that overexpression of the cardiac renin gene in hypertensive strains cou The objective of this study was to compare the gene expression of individual components of the renin-angiotensin system (RAS) in hearts of normotensive and hypertensive rats. Two genetically hypertensive rat strains - spontaneously hypertensive rats (SHR) and hereditary hypertriglyceridemic rats (HTG) - were compared with Wistar-Kyoto (WKY) and Lewis (LEW) normotensive controls. In addition, developmental changes in gene expression of individual components of cardiac RAS were studied in 20-day-old fetuses, 2-day-old newborns and 3-month-old HTG and LEW rats. Angiotensinogen gene expression did not differ either among adult normotensive and hypertensive strains, or during development. The renin gene expression was significantly increased in hypertensive heart when compared to normotensive one. There was also an age-dependent increase of ACE gene expression in both HTG and LEW rats, which was delayed in HTG hearts. Results suggest that overexpression of the cardiac renin gene in hypertensive strains cou (en)
Title	Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats. Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats. (en)
skos:prefLabel	Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats. Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats. (en)
skos:notation	RIV/67985823:_____/01:20010177!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany	35;42
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA7011805), Z(AV0Z5011922)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Kuneš, Jaroslav Dobešová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	677746
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:20010177
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	renin-angiotensin systém; - heart; - hypertension (en)
http://linked.open.../riv/klicoveSlovo	- heart - hypertension renin-angiotensin systém
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8C8CD05D3A23]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Oxygen free radicals and nitric oxide in the pathogenesis of age-dependent experimental hypertension: the attenuation of vasodilator mechanisms ...
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Kuneš, Jaroslav Dobešová, Zdeňka Križanová, O. Jurkovičová, D.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease
issn	0862-8408
number of pages	8 (xsd:int)

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