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  • We found that in SHR harboring the deletion variant of Cd36 (fatty acid transporter), transgenic expression of wild type Cd36 in modest amounts ameliorates defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue and second, exerts little or no effect on blood pressure. In conclusion, the current studies provide definitive evidence that mutant Cd36 is a QTL with major effect on insulin action, glucose tolerance, and serum fatty acid levels in the SHR/NIH strains.
  • We found that in SHR harboring the deletion variant of Cd36 (fatty acid transporter), transgenic expression of wild type Cd36 in modest amounts ameliorates defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue and second, exerts little or no effect on blood pressure. In conclusion, the current studies provide definitive evidence that mutant Cd36 is a QTL with major effect on insulin action, glucose tolerance, and serum fatty acid levels in the SHR/NIH strains. (en)
Title
  • Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.
  • Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. (en)
skos:prefLabel
  • Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.
  • Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. (en)
skos:notation
  • RIV/67985823:_____/01:20010171!RIV/2003/AV0/A20003/N
http://linked.open.../vavai/riv/strany
  • 156;158
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/00/1636), P(GV204/98/K015), P(LN00A079), Z(AV0Z5011922), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 699047
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/01:20010171
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cd36 (fatty acid transporter) (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [2693F32151D4]
http://linked.open...i/riv/nazevZdroje
  • Nature Genetics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Kazdová, L.
  • Křen, Vladimír
  • Kurtz, T. W.
  • Landa, Vladimír
  • Pravenec, Michal
  • Zídek, Václav
  • Aitman, T. J.
  • Musilová, Alena
  • Abumrad, N. A.
  • Glazier, A. M.
  • Qi, N.
  • Wang, J. M.
  • Ibrahimi, A.
  • St. Lezin, E. M.
http://linked.open...n/vavai/riv/zamer
issn
  • 1061-4036
number of pages
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