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  • Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluable RAGE or by reducing AGE-precusors via glyoxalase I. Glu111Ala polymorphism of glyoxalaseI gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Higher frequency of the mutated C allele was found in patients with negative estrogen receptors and in patients in clinical stage III compared to controls (P<0.05). The presence of the C allele could represent a negative prognostic factor; however, further studies are needed to confirm this hypothesis.
  • Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluable RAGE or by reducing AGE-precusors via glyoxalase I. Glu111Ala polymorphism of glyoxalaseI gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Higher frequency of the mutated C allele was found in patients with negative estrogen receptors and in patients in clinical stage III compared to controls (P<0.05). The presence of the C allele could represent a negative prognostic factor; however, further studies are needed to confirm this hypothesis. (en)
Title
  • Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer
  • Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer (en)
skos:prefLabel
  • Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer
  • Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer (en)
skos:notation
  • RIV/67985807:_____/09:00332958!RIV10-AV0-67985807
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z10300504), Z(MZ0VFN2005)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 316533
http://linked.open...ai/riv/idVysledku
  • RIV/67985807:_____/09:00332958
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • glyoxalase I; advanced glycation end products; breast cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [9AA2BF391F27]
http://linked.open...i/riv/nazevZdroje
  • Cancer Investigation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Zvára, Karel
  • Kalousová, M.
  • Zima, T.
  • Germanová, A.
  • Jáchymová, M.
  • Germanová, Al.
  • Tesarová, P.
http://linked.open...ain/vavai/riv/wos
  • 000267370700009
http://linked.open...n/vavai/riv/zamer
issn
  • 0735-7907
number of pages
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