| Attributes | Values |
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| rdf:type
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| Description
| - The internal ribosome entry site (IRES) is a part of the mRNA sequence which is able to attract the eukaryotic ribosomal initiation complex and to directly promote the initiation of protein synthesis independently of the presence of 5'-terminal 7mG cap. IRESs were first discovered in certain eukaryotic viruses where they very often play a pivotal role in viral strategies, allowing the viral invader to overcome the overall decrease of the host protein synthesis caused either by viral proteins or by the cellular antiviral defense system. Although the IRES segments were first described in viruses, extensive evidence has appeared in the past few years that a similar principle of the translation initiation is utilized also by some cellular mRNAs. This chapter presents the current status of the IRESite database (http://www.iresite.org), the complete list of known viral and cellular IRESs as well as novel results obtained from the comparative analyses of IRES segments accumulated to date.
- The internal ribosome entry site (IRES) is a part of the mRNA sequence which is able to attract the eukaryotic ribosomal initiation complex and to directly promote the initiation of protein synthesis independently of the presence of 5'-terminal 7mG cap. IRESs were first discovered in certain eukaryotic viruses where they very often play a pivotal role in viral strategies, allowing the viral invader to overcome the overall decrease of the host protein synthesis caused either by viral proteins or by the cellular antiviral defense system. Although the IRES segments were first described in viruses, extensive evidence has appeared in the past few years that a similar principle of the translation initiation is utilized also by some cellular mRNAs. This chapter presents the current status of the IRESite database (http://www.iresite.org), the complete list of known viral and cellular IRESs as well as novel results obtained from the comparative analyses of IRES segments accumulated to date. (en)
- Práce sumarizuje stav současného poznání o interních vazebných místech pro ribozóm (IRES) a analyzuje na základě dat soustředěných v databázi IRESite (http://www.iresite.org) některé jejich vlastnosti. IRES se nacházejí nejčastěji v 5' nepřekládaných oblastech RNA některých virů a buněčných transkriptů, kde umožňují překlad příslušných mRNA i v případě, kdy je celková úroveň buněčné proteosyntézy významně snížena, například při virové infekci, při buněčném stresu, při apoptóze atd. (cs)
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| Title
| - A Bioinformatical Approach to the Analysis of Viral and Cellular Internal Ribosome Entry Sites
- A Bioinformatical Approach to the Analysis of Viral and Cellular Internal Ribosome Entry Sites (en)
- Bioinformatický přístup k analýze virových a buněčných interních vazebných míst pro ribozóm (cs)
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| skos:prefLabel
| - A Bioinformatical Approach to the Analysis of Viral and Cellular Internal Ribosome Entry Sites
- A Bioinformatical Approach to the Analysis of Viral and Cellular Internal Ribosome Entry Sites (en)
- Bioinformatický přístup k analýze virových a buněčných interních vazebných míst pro ribozóm (cs)
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| skos:notation
| - RIV/67985807:_____/07:00096578!RIV08-AV0-67985807
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M06014), P(GA204/03/1487), P(GA301/07/0607), P(LC06066), Z(AV0Z10300504), Z(MSM0021620813)
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/67985807:_____/07:00096578
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - IRES; mRNA; translation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - New Messenger RNA Research Communications
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Mašek, T.
- Pospíšek, Martin
- Mokrejš, M.
- Vopálenský, V.
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| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| |
| https://schema.org/isbn
| |
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