About: Enzyme allocation problems in kinetic metabolic networks: Optimal solutions are elementary flux modes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The survival and proliferation of cells and organisms require a highly coordinated allocation of cellular resources to ensure the efficient synthesis of cellular components. In particular, the total enzymatic capacity for cellular metabolism is limited by finite resources that are shared between all enzymes, such as cytosolic space, energy expenditure for amino-acid synthesis, or micro-nutrients. While extensive work has been done to study constrained optimization problems based only on stoichiometric information, mathematical results that characterize the optimal flux in kinetic metabolic networks are still scarce. Here, we study constrained enzyme allocation problems with general kinetics, using the theory of oriented matroids. We give a rigorous proof for the fact that optimal solutions of the non-linear optimization problem are elementary flux modes. This finding has significant consequences for our understanding of optimality in metabolic networks as well as for the identification of metabolic switches and the computation of optimal flux distributions in kinetic metabolic networks The survival and proliferation of cells and organisms require a highly coordinated allocation of cellular resources to ensure the efficient synthesis of cellular components. In particular, the total enzymatic capacity for cellular metabolism is limited by finite resources that are shared between all enzymes, such as cytosolic space, energy expenditure for amino-acid synthesis, or micro-nutrients. While extensive work has been done to study constrained optimization problems based only on stoichiometric information, mathematical results that characterize the optimal flux in kinetic metabolic networks are still scarce. Here, we study constrained enzyme allocation problems with general kinetics, using the theory of oriented matroids. We give a rigorous proof for the fact that optimal solutions of the non-linear optimization problem are elementary flux modes. This finding has significant consequences for our understanding of optimality in metabolic networks as well as for the identification of metabolic switches and the computation of optimal flux distributions in kinetic metabolic networks (en)
Title	Enzyme allocation problems in kinetic metabolic networks: Optimal solutions are elementary flux modes Enzyme allocation problems in kinetic metabolic networks: Optimal solutions are elementary flux modes (en)
skos:prefLabel	Enzyme allocation problems in kinetic metabolic networks: Optimal solutions are elementary flux modes Enzyme allocation problems in kinetic metabolic networks: Optimal solutions are elementary flux modes (en)
skos:notation	RIV/67179843:_____/14:00441169!RIV15-AV0-67179843
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0256)
http://linked.open...iv/cisloPeriodika	APR 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Steuer, Ralf Müller, Stefan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Centrum výzkumu globální změny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	14818
http://linked.open...ai/riv/idVysledku	RIV/67179843:_____/14:00441169
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metabolic optimization; enzyme kinetics; oriented matroid; elementary vector; conformal sum (en)
http://linked.open.../riv/klicoveSlovo	conformal sum elementary vector metabolic optimization oriented matroid enzyme kinetics
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[38625546D4A5]
http://linked.open...i/riv/nazevZdroje	Journal of Theoretical Biology
http://linked.open...in/vavai/riv/obor	EI
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Local team and international consortium for computational modelling of a cyanobacterial cell
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	347
http://linked.open...iv/tvurceVysledku	Steuer, Ralf Müller, Stefan Regensburger, G.
http://linked.open...ain/vavai/riv/wos	000334977300018
issn	0022-5193
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jtbi.2013.11.015

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