About: Safety of amisulpride in combination with antidepressants under common clinical practice conditions

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The main objective was to identify the occurrence of adverse events associated with amisulpride when combined with antidepressants (ADs). Methods. A non-interventional questionnaire-based study focussed on identification of occurrence and tolerance of combinations of amisulpride with ADs under common clinical practice conditions. Results. Combinations of amisulpride with ADs were administered to 3178 patients suffering from depression. The average daily dose of amisulpride was 54.8 +/-+/- 17 mg (range 50--150 mg/day). The most frequently administered ADs were SSRIs. A total of 4463 adverse events were recorded in 1624 (51%) of all treated patients. The most frequent adverse event was weight gain, followed by headache, fatigue and sleepiness. Only 2% of all adverse events were evaluated as adverse events of medium or high intensity. Higher occurrences of some adverse events were noted for specific combinations. Conclusion. The main objective was to identify the occurrence of adverse events associated with amisulpride when combined with antidepressants (ADs). Methods. A non-interventional questionnaire-based study focussed on identification of occurrence and tolerance of combinations of amisulpride with ADs under common clinical practice conditions. Results. Combinations of amisulpride with ADs were administered to 3178 patients suffering from depression. The average daily dose of amisulpride was 54.8 +/-+/- 17 mg (range 50--150 mg/day). The most frequently administered ADs were SSRIs. A total of 4463 adverse events were recorded in 1624 (51%) of all treated patients. The most frequent adverse event was weight gain, followed by headache, fatigue and sleepiness. Only 2% of all adverse events were evaluated as adverse events of medium or high intensity. Higher occurrences of some adverse events were noted for specific combinations. Conclusion. (en)
Title	Safety of amisulpride in combination with antidepressants under common clinical practice conditions Safety of amisulpride in combination with antidepressants under common clinical practice conditions (en)
skos:prefLabel	Safety of amisulpride in combination with antidepressants under common clinical practice conditions Safety of amisulpride in combination with antidepressants under common clinical practice conditions (en)
skos:notation	RIV/65269705:_____/11:#0001448!RIV12-MZ0-65269705
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Češková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	228065
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/11:#0001448
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	depression (en)
http://linked.open.../riv/klicoveSlovo	depression
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4F32A6C28261]
http://linked.open...i/riv/nazevZdroje	International Journal of Psychiatry in Clinical Practice
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Češková, Eva
http://linked.open...ain/vavai/riv/wos	000290270900011
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1365-1501
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/13651501.2010.544744

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