About: Assessment of adenosine triphosphate-binding cassette subfamily B member 1(ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types

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About: Assessment of adenosine triphosphate-binding cassette subfamily B member 1(ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The ABCB1 gene encodes P-glycoprotein, a member of the multi-drug resistance protein subfamily B, which plays a role in the cell efflux of imatinib mesylate (IMA). Although some conflicting results have been reported, it is generally accepted that overexpression of the ABCB1 gene leads to the upregulation of P-glycoprotein (i.e.ABCB1) and the subsequent increase of IMA efflux, which has been postulated to be an important mechanism of drug resistance in CML (1). Despite an abundance of literature that discusses ABCB1 biology, only limited data exist that have explored the relationship between ABCB1 expression or activity and the prediction of treatment response in patients with chronic myelogenous leukemia (CML) (2-5). The ABCB1 gene encodes P-glycoprotein, a member of the multi-drug resistance protein subfamily B, which plays a role in the cell efflux of imatinib mesylate (IMA). Although some conflicting results have been reported, it is generally accepted that overexpression of the ABCB1 gene leads to the upregulation of P-glycoprotein (i.e.ABCB1) and the subsequent increase of IMA efflux, which has been postulated to be an important mechanism of drug resistance in CML (1). Despite an abundance of literature that discusses ABCB1 biology, only limited data exist that have explored the relationship between ABCB1 expression or activity and the prediction of treatment response in patients with chronic myelogenous leukemia (CML) (2-5). (en)
Title	Assessment of adenosine triphosphate-binding cassette subfamily B member 1(ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types Assessment of adenosine triphosphate-binding cassette subfamily B member 1(ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types (en)
skos:prefLabel	Assessment of adenosine triphosphate-binding cassette subfamily B member 1(ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types Assessment of adenosine triphosphate-binding cassette subfamily B member 1(ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types (en)
skos:notation	RIV/65269705:_____/11:#0001229!RIV12-MZ0-65269705
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622430), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Žáčková, Daniela Rázga, Filip Ráčil, Z. Dvořáková, Dana Mayer, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	187240
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/11:#0001229
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mRNA exprese (en)
http://linked.open.../riv/klicoveSlovo	mRNA exprese
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[ECB5AE76A595]
http://linked.open...i/riv/nazevZdroje	Leukemia & Lymphoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Dvořáková, Dana Mayer, Jiří Rázga, Filip Ráčil, Zdeněk Žáčková, Daniela
http://linked.open...ain/vavai/riv/wos	000287089100027
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1042-8194
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/10428194.2010.533220

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