About: Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance

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About: Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We evaluated the performance of a galactomannan (GM) assay in bronchoalveolar lavage (BAL) fluid compared to serum samples for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematological diseases. Results: Twenty-eight cases of IPA (11%) were diagnosed. The highest sensitivity (78.6%) with good specificity (98.6%) was obtained with a triple detection of GM in bronchial, alveolar, and serum samples. Neutropenia and antifungal therapy for only 24 h increased the sensitivity, while antifungal treatment for more than 2 days decreased assay performance.Conclusions: In contrast to recently published data, we found only moderate sensitivity, but high specificity and high positive predictive value of the detection of GM in BAL fluid. We evaluated the performance of a galactomannan (GM) assay in bronchoalveolar lavage (BAL) fluid compared to serum samples for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematological diseases. Results: Twenty-eight cases of IPA (11%) were diagnosed. The highest sensitivity (78.6%) with good specificity (98.6%) was obtained with a triple detection of GM in bronchial, alveolar, and serum samples. Neutropenia and antifungal therapy for only 24 h increased the sensitivity, while antifungal treatment for more than 2 days decreased assay performance.Conclusions: In contrast to recently published data, we found only moderate sensitivity, but high specificity and high positive predictive value of the detection of GM in BAL fluid. (en)
Title	Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance (en)
skos:prefLabel	Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance (en)
skos:notation	RIV/65269705:_____/11:#0001225!RIV12-MZ0-65269705
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10441), P(NS10442)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Skřičková, Jana Volfová, Pavlína Kocmanová, I. Tošková, Martina Ráčil, Z. Lengerová, Martina Mayer, Jiří Weinbergerová, Barbora Hrnčířová, Kristýna Winterová, Jana Rolencová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	200779
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/11:#0001225
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hematological malignancy (en)
http://linked.open.../riv/klicoveSlovo	hematological malignancy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9764573F913C]
http://linked.open...i/riv/nazevZdroje	International Journal of Infectious Diseases
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Monitoring of voriconazole plasma levels Importance of non-culture methods for diagnostics of invasive fungal infections caused by filamentous fungi from bronchoalveolar lavage fluid in hematooncological patients
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Lengerová, Martina Mayer, Jiří Ráčil, Zdeněk Skřičková, Jana Tošková, Martina Volfová, Pavlína Kocmanová, Iva Hrnčířová, Kristýna Rolencová, Monika Weinbergerová, Barbora Winterová, Jana
http://linked.open...ain/vavai/riv/wos	000298114700014
issn	1201-9712
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijid.2011.09.011

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