About: Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs

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About: Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Following a trauma, the capacity of the growth plate to regenerate tends to decrease. Evaluating the capacity of mesenchymal stem cells (MSCs) to heal defects in the injured physis is one of the current issues of contemporary research. Our study draws on a successful experiment with similar objectives which was previously carried out on the model of a New Zealand white rabbit. Long-term research included a group of 10 miniature pigs: allogeneic mesenchymal stem cells were transplanted into an iatrogenically-induced defect in the lateral section of the distal physis of the left femur. The right femur with the same defect in the distal physis, but without transplanted stem cells, served as a control. To transfer MSCs, a recently developed porous scaffold was used, based on collagen and chitosan, constituting a compact tube into which MSCs were implanted. The pigs were euthanized 4 months after the transplantation. Following a trauma, the capacity of the growth plate to regenerate tends to decrease. Evaluating the capacity of mesenchymal stem cells (MSCs) to heal defects in the injured physis is one of the current issues of contemporary research. Our study draws on a successful experiment with similar objectives which was previously carried out on the model of a New Zealand white rabbit. Long-term research included a group of 10 miniature pigs: allogeneic mesenchymal stem cells were transplanted into an iatrogenically-induced defect in the lateral section of the distal physis of the left femur. The right femur with the same defect in the distal physis, but without transplanted stem cells, served as a control. To transfer MSCs, a recently developed porous scaffold was used, based on collagen and chitosan, constituting a compact tube into which MSCs were implanted. The pigs were euthanized 4 months after the transplantation. (en)
Title	Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs (en)
skos:prefLabel	Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs (en)
skos:notation	RIV/65269705:_____/10:#0001196!RIV11-MZ0-65269705
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS9896)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Gál, Petr Křen, L. Plánka, Ladislav Starý, David
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	293387
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/10:#0001196
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mesenchymal stem cells (en)
http://linked.open.../riv/klicoveSlovo	mesenchymal stem cells
http://linked.open...ontrolniKodProRIV	[C09A77C9066D]
http://linked.open...in/vavai/riv/obor	FI
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanotechnology and tissue engineering used in growth plate arrest therapy - experimental study
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Křen, Leoš Gál, Petr Plánka, Ladislav Starý, D.

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