About: Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma

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About: Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell lineage: B-cells and plasma cells (PCs). Using immunofluorescent staining, it was shown that CA in B-cells is present in 3.2+/-2.5% in healthy donors versus 9.9+/-7.9% in MM patients (p<0.0001). Based on the calculated threshold value of CA in B-cells, 37% (14/38) of MM patients were positive. There was no significant correlation between CA-positive MM cases (based on PC samples evaluation) and the occurrence of cytogenetic abnormalities in PCs, including del(13)(q14), del(17)(p13), gain(1)(q21) and hyperdiploidy. Copyright (c) 2010 Elsevier Ltd. All rights reserved. Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell lineage: B-cells and plasma cells (PCs). Using immunofluorescent staining, it was shown that CA in B-cells is present in 3.2+/-2.5% in healthy donors versus 9.9+/-7.9% in MM patients (p<0.0001). Based on the calculated threshold value of CA in B-cells, 37% (14/38) of MM patients were positive. There was no significant correlation between CA-positive MM cases (based on PC samples evaluation) and the occurrence of cytogenetic abnormalities in PCs, including del(13)(q14), del(17)(p13), gain(1)(q21) and hyperdiploidy. Copyright (c) 2010 Elsevier Ltd. All rights reserved. (en)
Title	Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma (en)
skos:prefLabel	Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma (en)
skos:notation	RIV/65269705:_____/10:#0001036!RIV11-MZ0-65269705
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06027), P(NR9317), P(NS10406), Z(MSM0021622415), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kuglík, Petr Hájek, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	249931
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/10:#0001036
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma (en)
http://linked.open.../riv/klicoveSlovo	multiple myeloma
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0DF74A9A92C2]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	University Research Centre - Czech Myeloma Group Creating of prognostic panel in patients with monoclonal gammopathy of undetermined significance with a target to prevent the risk of malignant transformation. Prognostic significance of clonal chromosome aberration in new methods of multiple myeloma treatment
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Hájek, Roman Kuglík, Petr
http://linked.open...ain/vavai/riv/wos	000278601600011
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0145-2126
number of pages	5 (xsd:int)

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