About: Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX ihibitors: An expression profiling study.

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Expression profiling of 440 cancer-related genes in two neuroblastoma cell lines, SK-N-BE(2) a SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and LOX/COX inhibitors was performed. Cluster analyses of the changes in gene expression showed the concentration-dependent increase in genes known to be involved in the process of retinoid-induced neuronal differentiation, especially in cytoskeleton remodeling. These changes were detected in both cell lines, and they were independent of the type of specific inhibitors, suggesting a common mechanism of ATRA-induced differentiation enhancement. Expression profiling of 440 cancer-related genes in two neuroblastoma cell lines, SK-N-BE(2) a SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and LOX/COX inhibitors was performed. Cluster analyses of the changes in gene expression showed the concentration-dependent increase in genes known to be involved in the process of retinoid-induced neuronal differentiation, especially in cytoskeleton remodeling. These changes were detected in both cell lines, and they were independent of the type of specific inhibitors, suggesting a common mechanism of ATRA-induced differentiation enhancement. (en)
Title	Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX ihibitors: An expression profiling study. Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX ihibitors: An expression profiling study. (en)
skos:prefLabel	Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX ihibitors: An expression profiling study. Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX ihibitors: An expression profiling study. (en)
skos:notation	RIV/65269705:_____/10:#0001003!RIV11-MZ0-65269705
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9341)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Veselská, Renata Štěrba, Jaroslav Zitterbart, Karel Hermanová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	257230
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/10:#0001003
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trans - retionic acid (en)
http://linked.open.../riv/klicoveSlovo	Trans
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[927F632BC2D3]
http://linked.open...i/riv/nazevZdroje	Journal of Experimental and Clinical Cancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of antineoplastic effect of retinoids by LOX/COX inhibitors on the model of solid childhood tumors: in vitro study
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Hermanová, Markéta Veselská, Renata Zitterbart, Karel Štěrba, Jaroslav
http://linked.open...ain/vavai/riv/wos	000278275400001
issn	1756-9966
number of pages	8 (xsd:int)

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