About: Efficacy of pregabalin in neuropathic pain in paediatric oncological patients.

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About: Efficacy of pregabalin in neuropathic pain in paediatric oncological patients. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	To evaluate the safety and efficacy of pregabalin in the management of chemotherapy-induced neuropathic pain in patients with childhood solid tumors and leukaemia. In an open-label study, 30 children (11 boys and 19 girls; mean age 13.5 years) who were treated for solid tumors and leukaemia, and developed a painful peripheral neuropathy, were medicated with pregabalin in the daily dose of 150-300 mg for 8 weeks. RESULTS: Twenty-eight patients completed the 8-week follow-up. A significant and long-lasting pain relief was noted in 86% of these patients. Median VAS score decreased by 59% at the 8th week from baseline. Adverse effects were infrequent and transient. The treatment with pregabalin resulted in a significant improvement in pain symptoms. The use of pregabalin in children is off-label so far. However, this drug seems to be a safe and effective remedy, which could significantly broaden the therapeutic spectrum in paediatric oncological patients suffering from neuropathic pain. To evaluate the safety and efficacy of pregabalin in the management of chemotherapy-induced neuropathic pain in patients with childhood solid tumors and leukaemia. In an open-label study, 30 children (11 boys and 19 girls; mean age 13.5 years) who were treated for solid tumors and leukaemia, and developed a painful peripheral neuropathy, were medicated with pregabalin in the daily dose of 150-300 mg for 8 weeks. RESULTS: Twenty-eight patients completed the 8-week follow-up. A significant and long-lasting pain relief was noted in 86% of these patients. Median VAS score decreased by 59% at the 8th week from baseline. Adverse effects were infrequent and transient. The treatment with pregabalin resulted in a significant improvement in pain symptoms. The use of pregabalin in children is off-label so far. However, this drug seems to be a safe and effective remedy, which could significantly broaden the therapeutic spectrum in paediatric oncological patients suffering from neuropathic pain. (en)
Title	Efficacy of pregabalin in neuropathic pain in paediatric oncological patients. Efficacy of pregabalin in neuropathic pain in paediatric oncological patients. (en)
skos:prefLabel	Efficacy of pregabalin in neuropathic pain in paediatric oncological patients. Efficacy of pregabalin in neuropathic pain in paediatric oncological patients. (en)
skos:notation	RIV/65269705:_____/09:#0000836!RIV10-MZ0-65269705
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(GA406/07/1384), V
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Štěrba, Jaroslav Vondráček, Petr Gál, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	312476
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/09:#0000836
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antineoplastic agents; neoplasms (en)
http://linked.open.../riv/klicoveSlovo	antineoplastic agents neoplasms
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FBF535CE7147]
http://linked.open...i/riv/nazevZdroje	European Journal of Paediatric Neurology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Quality of life in children surviving cancer: A developmental approach
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Štěrba, Jaroslav Vondráček, Petr Gál, Petr
http://linked.open...ain/vavai/riv/wos	000267620800006
issn	1090-3798
number of pages	5 (xsd:int)

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