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Description
| - B-cell chronic lymphocytic leukemia (CLL) is an incurable disease with a highly variable clinical course. A proportion of patients eventually progress to a higher stage of malignancy. A recent association has been observed between the presence of aberrant somatic hypermutations in leukemic cells (hypermutations occurring outside of the immunoglobulin locus) and the transformation to a diffuse large B-cell lymphoma or prolymphocytic leukemia. In this study, we report on the rarely observed blastic transformation in a CLL patient who had previously been shown to harbor aberrant somatic hypermutations in the TP53 tumor-suppressor gene (Mol Immunol 2008;45:1525-29). The enzyme responsible, the activation-induced cytidine deaminase, was still active within the transformation, as evidenced by the ongoing class-switch recombination of cytoplasmic immunoglobulins.
- B-cell chronic lymphocytic leukemia (CLL) is an incurable disease with a highly variable clinical course. A proportion of patients eventually progress to a higher stage of malignancy. A recent association has been observed between the presence of aberrant somatic hypermutations in leukemic cells (hypermutations occurring outside of the immunoglobulin locus) and the transformation to a diffuse large B-cell lymphoma or prolymphocytic leukemia. In this study, we report on the rarely observed blastic transformation in a CLL patient who had previously been shown to harbor aberrant somatic hypermutations in the TP53 tumor-suppressor gene (Mol Immunol 2008;45:1525-29). The enzyme responsible, the activation-induced cytidine deaminase, was still active within the transformation, as evidenced by the ongoing class-switch recombination of cytoplasmic immunoglobulins. (en)
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Title
| - Inactivation of p53 and amplification of MYCN gene in terminal lymphoblastic relapse in chronic lymphotic leukemia patient
- Inactivation of p53 and amplification of MYCN gene in terminal lymphoblastic relapse in chronic lymphotic leukemia patient (en)
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skos:prefLabel
| - Inactivation of p53 and amplification of MYCN gene in terminal lymphoblastic relapse in chronic lymphotic leukemia patient
- Inactivation of p53 and amplification of MYCN gene in terminal lymphoblastic relapse in chronic lymphotic leukemia patient (en)
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skos:notation
| - RIV/65269705:_____/09:#0000819!RIV10-MZ0-65269705
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LC06027), P(NR9293), V, Z(MSM0021622430)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Pospíšilová, Šárka
- Brychtová, Yvona
- Doubek, Michael
- Mayer, Jiří
- Tichý, Boris
- Stano Kozubík, Kateřina
- Šmardová, Jana
- Malčíková, Jitka
- Trbušek, Martin
- Borský, Marek
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/65269705:_____/09:#0000819
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - CLL transformation; gene amplification; chronic lymphocytic leukemia (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Cancer Genetics and Cytogenetics
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brychtová, Yvona
- Doubek, Michael
- Mayer, Jiří
- Pospíšilová, Šárka
- Tichý, Boris
- Malčíková, Jitka
- Trbušek, Martin
- Šmardová, Jana
- Borský, Marek
- Staňo Kozubík, Kateřina
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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