About: Paliperidon mediated modification of cortical inhibition

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission. Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission. (en)
Title	Paliperidon mediated modification of cortical inhibition Paliperidon mediated modification of cortical inhibition (en)
skos:prefLabel	Paliperidon mediated modification of cortical inhibition Paliperidon mediated modification of cortical inhibition (en)
skos:notation	RIV/65269705:_____/09:#0000799!RIV10-MZ0-65269705
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS9890), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	30
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Češková, Eva Přikryl, Radovan Přikrylová Kučerová, Hana Ustohal, Libor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	332557
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/09:#0000799
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cortical silent period; first episode; paliperidon; schizophrenia (en)
http://linked.open.../riv/klicoveSlovo	cortical silent period schizophrenia first episode paliperidon
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[A265145363C9]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional brain correlates related to negative symptoms of schizophrenia treatment by repetitive transcranial magnetic stimulation
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	2009
http://linked.open...iv/tvurceVysledku	Přikryl, Radovan Ustohal, Libor Češková, Eva Přikrylová-Kučerová, Hana
http://linked.open...ain/vavai/riv/wos	000272199300018
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	0172-780X
number of pages	4 (xsd:int)

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