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Description
| - The aim of our study was to evaluate the concentration changes in the proangiogenic hepatocyte growth factor (HGF) and antiangiogenic endostatin during the sampling of large bone marrow volumes in patients with multiple myeloma. HGF and endostatin concentrations were measured in the 1st ml, the 5th ml, the 19th ml, the 30th ml, and the 45th ml of the sample. Concentrations of HGF, which is produced by bone marrow and myeloma cells, decreased significantly in the course of BM sampling due to the admixture of peripheral blood. Endostatin concentrations did not change significantly during the procedure of sampling, as endostatin is mainly secreted by the parenchymatous organs such as liver, lungs, and others. In conclusion, the admixture of the peripheral blood could be partly responsible for conflicting results of studies of HGF in multiple myeloma. Standardisation of HGF sampling is required for valid comparisons between different studies.
- The aim of our study was to evaluate the concentration changes in the proangiogenic hepatocyte growth factor (HGF) and antiangiogenic endostatin during the sampling of large bone marrow volumes in patients with multiple myeloma. HGF and endostatin concentrations were measured in the 1st ml, the 5th ml, the 19th ml, the 30th ml, and the 45th ml of the sample. Concentrations of HGF, which is produced by bone marrow and myeloma cells, decreased significantly in the course of BM sampling due to the admixture of peripheral blood. Endostatin concentrations did not change significantly during the procedure of sampling, as endostatin is mainly secreted by the parenchymatous organs such as liver, lungs, and others. In conclusion, the admixture of the peripheral blood could be partly responsible for conflicting results of studies of HGF in multiple myeloma. Standardisation of HGF sampling is required for valid comparisons between different studies. (en)
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Title
| - Evaluation of HGF and Endostati in the Bone Marrow of Patients wtih Multiple Myeloma and the Effect of Peripheral Blood Admixture
- Evaluation of HGF and Endostati in the Bone Marrow of Patients wtih Multiple Myeloma and the Effect of Peripheral Blood Admixture (en)
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skos:prefLabel
| - Evaluation of HGF and Endostati in the Bone Marrow of Patients wtih Multiple Myeloma and the Effect of Peripheral Blood Admixture
- Evaluation of HGF and Endostati in the Bone Marrow of Patients wtih Multiple Myeloma and the Effect of Peripheral Blood Admixture (en)
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skos:notation
| - RIV/65269705:_____/09:#0000797!RIV10-MZ0-65269705
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/65269705:_____/09:#0000797
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Adam, Zdeněk
- Hájek, Roman
- Penka, Miroslav
- Vorlíček, Jiří
- Pour, L.
- Kovářová, Lucie
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number of pages
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