About: In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells.

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About: In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma has been considered a weakly immunogenic malignancy that can cause profound defects in the immune system. An important issue for the immunotherapy of myeloma is the identification of appropriate tumor-associated antigens (TAAs). Recently, hTERT (human telomerase reverse transcriptase) was detected on a majority of human malignancies. In the studies reported here, we studied antigen-specific and HLA-A2-restricted cytotoxic activity against an ARH77 myeloma cell line in vitro. An HLA-A2-specific hTERT-derived nonapeptide ((540)ILAKFLHWL(548)) was used as a TAA. Myeloma-specific cytotoxic activity of hTERT-reactive cytotoxic lymphocytes (CTLs) was established by repeated stimulation of the CTLs via dendritic cells loaded with hTERT-derived nonapeptide Multiple myeloma has been considered a weakly immunogenic malignancy that can cause profound defects in the immune system. An important issue for the immunotherapy of myeloma is the identification of appropriate tumor-associated antigens (TAAs). Recently, hTERT (human telomerase reverse transcriptase) was detected on a majority of human malignancies. In the studies reported here, we studied antigen-specific and HLA-A2-restricted cytotoxic activity against an ARH77 myeloma cell line in vitro. An HLA-A2-specific hTERT-derived nonapeptide ((540)ILAKFLHWL(548)) was used as a TAA. Myeloma-specific cytotoxic activity of hTERT-reactive cytotoxic lymphocytes (CTLs) was established by repeated stimulation of the CTLs via dendritic cells loaded with hTERT-derived nonapeptide (en)
Title	In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. (en)
skos:prefLabel	In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. (en)
skos:notation	RIV/65269705:_____/09:#0000778!RIV10-MZ0-65269705
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1A8709), P(LC06023), P(LC06027)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Říhová, Lucie Hájek, Roman Michálek, Jaroslav Burešová, Ivana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	318912
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/09:#0000778
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma; T-lymphocyte (en)
http://linked.open.../riv/klicoveSlovo	multiple myeloma T-lymphocyte
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1F11A3C47E9A]
http://linked.open...i/riv/nazevZdroje	Journal of immunotoxicology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	In vitro separation and molecular analysis of graft-versus-host-specific and graft-versus-tumor-specific T cells Integrated bioanalytical technologies for microanalyses and diagnostics with laser induced fluorescence and mass spectrometry coupling. University Research Centre - Czech Myeloma Group
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Hájek, Roman Michálek, Jaroslav Kovářová, Lucie Burešová, Ivana
http://linked.open...ain/vavai/riv/wos	000275001500006
issn	1547-691X
number of pages	5 (xsd:int)

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